糖心乐治疗糖尿病性心肌病的实验研究

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1、陕西中医学院硕士学位论文糖心乐治疗糖尿病性心肌病的实验研究姓名：王凤申请学位级别：硕士专业：中西医结合基础生理学指导教师：丁延平20070501xinLeindiabeticcardiomyopathyAbstractMethodsADCmode10htheabd0m•na1caV•f0rf0urweeks,thendeX0fweretested■andtheeXptheSDmousewasbftyforabouteightwebloodsugar,bloodTC,HDL_cHaressionofTNF——amRNAwasdeteveyTXLtranscr•1Ptase

2、——P01ymetricrec0peande]ectrica1m•crosc0Pewereusedt00bservethucture•actionoandtheoptica1microsemyocardia1u1tra—micr0strObjectiveFromthepointsofsugarmetabolism,1ipoidosis,hemorhcology,m01ccu1arb•101ogyandh•1st010gy，thccXpcr•1mcntswerecarr•1ed0utt0kn0wab0utthccffccts0fTang—X•1nLc(TXL)9ach•1

3、nesedrug,0nthcb100dg1uc0se9b100dTC9HDL—cH,andthcu1trastructurc0fmy0cardialcc11s0fthcDcm0use♦Path0gen•cmechan•sm0fD•abeticcard•0my0Pathy(DC)waseXp10redandthetheraPymechanism0fTXLt0theDCwasd•scussedPre1iminar•1y•Th•sresearchhas1a•1dag00dthe0rct•1ca1f0undat•10nf0rthcc1•1nicapP1•1cati0n0fthe

4、TXL・Rcsu1ts1・TherearesignificantdiffercnccsbctweentreatmentgrouPsandn0rma1gr0uPinb1oodglue0sc,b10odTc,HDL—cH,P<0.01.Aftertreatmcnt9thclevelsofbloodglucoseinal1LherapeuLicgroupsarelowerLhanLhaLinmode1group,P<0・05。andthehigherdosegroupshowsbettereffect•2•Hemorheologyofa11treatmentgroupsare

5、improvedcontrastedwithmode13.0urdatapresentthatincreasedmyocardia1TNF一QexpressioninmRNA1eve1sisassociatedwithdiabeticmyocardiopathy・Thestudyshowsthattumornecrosisfactora1phaisdown—regu1ationindiabeticmyocardiopathybyusingTXIo4.Theobservationofmyocardialultrastruetureshowsmyoarchitectonic

6、derangementoftypicalmyocomma,widedparazone,widenedspacebetweenintercalateddisks,myofibri1lardegenerationfragmentationandvacuo1ization,mLtochondrialcompensatoryproliferationswe11ingshortenedcristaandrhegmaofmembrane.Thereisa1argequantityofglycogenthatdepositinthemodelgrouprats^yocardia1ti

7、ssue・Lipiddropletsandg1ychemoCone1aysapethedeerioptheandrotTCandHDL—CHoandtheepressInbrief・TXLdoesdeservetothefurtherinVestigationandc1•1nica1uge■KeyW0rdsD•1abeticCardiomy0r—0•hem0rheo10gy；u1card■1a1ce11S■exprofgeneamRNAincardiacmuscletissuesapathy；TangXinLe:Tumornecrosis