曲美他嗪改善扩张型心肌病心力衰竭患者心功能的疗效观察

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1、曲美他嗪改善扩张型心肌病心力衰竭患者心功能的疗效观察赵新国［摘要］目的探讨曲美他嗓对改善扩张型心肌病合并心力衰竭想者心功能的临床效果。方法将82例扩张型心肌病合并心力衰竭患者随机分为两组，所有患者均给予常规抗心力衰蜩治疗，观察组(41例)在此基础上加用曲美他嗪治疗，对照组(41例)则不给予曲美他嗪.观察治疗前后两组患者心功能改善程度•超声心动图测量计算左心室射血分数、左心室舒张末期内径及每分钟心排扯的变化。结果治疗12周后，对照组治疗总右效率为68.29%(28/41〉・观察组总右效率为87.80%(36/41),两者比较差异有统计学意义(PV0.05)；阿组治疗后

2、左室射血分数、毎分钟心排诡、左心室舒张末期内径等指标均较治疗前有显著改髀，差异有统计学意义(P<0.05)；且观察组治疗后上述指标明显优于对照组，差异有统计学意义(P<0.05)o结论曲美他嗪具有良好的抗心肌缺血、改善心肌能址代谢的作用，能够明显改善扩张熨心肌病心力衰竭患者心功能。［关键词］曲芙他嗪；扩张型心肌病；心力衰竭；心功能［中图分类号］R972+.3iR542.2；R541.6+l［文献标志码］B［文章编号］10033427(2011)04-0211・03Clinicaltherapeuticeffectivenessoftrimetazidineonthe

3、treatmentofpatientswithdilatedcardiomyopathyassociatedwithchroniccongestiveheartfailureZHAOXin-guo(DepartmentofCardiology,ZhejiangGeneralCorpsofArmedPoliceForcesHospital,ZhejiangProvince,Jiaxing314000,China)［Abstract^ObjectiveToexploretheclinicaltherapeuticeffectivenessoftrimetazidineo

4、nthetreatmentofdilatedcardiomyopathy(DCM)associatedwithchroniccongestiveheartfailure(CHF).MethodsEightytwopatientswithDCMassociatedwithCHFwererandom-lydividedinto2groups：thecontrolgroup(并=41)andtheobservationgroup(n=41)•Pa・tientsinthecontrolgroupweregivenroutinetreatment.Patientsintheo

5、bservationgroupweretreatedwithtrimetazidineonthebasisoftheroutinetreatment•Thecourseoftreatmentlasted12weeks.Thegradeofcardiacfunctiontleftventricularejectionfraction(LVEF)tleftventricularinternaldiameteratenddiastolicdiameter(LVIDd)andcardiacoutput(CO)weredetermined.ResultsAfter12week

6、softreatmentsthetotaleffectiverateinthecontrolgroupwas68.29%(28/41),andintheobservationgroupwas87・80%(36/41),thedifferencewasstatisticallysignificant(PV0.05).JnbothgroupsthelevelofLVIDdtCO>LVEFweresignificantlyimprovedcomparedwithbeforethetreatment(PV0.05),andtheindexintheobservationgr

7、oupwerebetterthanthecontrolgroup(PV0.05).ConclusionTrimetazidinehasagoodeffectofanti-myocardialischemiaandcanimprovemyocardialenergymetabolism>andleftcardiacfunction.［Keywords］Trimetazidine；Dilatedcardiomyopathy；Heartfailure；Cardiacfunction扩张型心肌病(dilatedcardiomyopathytDCM)是以一侧左心室或双侧心