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1、乳腺癌脑转移103例临床分析申戈宋三泰江泽飞吴世凯王涛张少华卢新友曾敏黄红艳丁丽娟杜萌军事医学科学院附属医院肿瘤中心北京100071［摘要］背景和目的：乳腺癌发病率越来越高，在全身病变得到控制下，脑转移成为治疗的难点，本文对我院乳腺癌脑转移的临床特点进行了总结，以期得出乳腺癌脑转移预后及治疗的初步结果。方法：收集1978年8月至2008年11月在我院就诊患者的病例资料，包括无病生存时间、脑转移时间、淋巴结转移情况、受体情况，以及脑转移后治疗情况、放疗后生存情况等，对各种情况的出现时间以及不同治疗对生存时间的影响
2、进行分析。结果：共收集103例乳腺癌脑转移患者的临床资料，ER和/或PR阴性、Her-2高表达者无病生存时间及到脑转移时间均明显短于ER和/或PR阳性、Her-2低表达者。全脑放疗加局部治疗生存时间明显长于单行全脑放疗者。结论：乳腺癌患者受体情况对无病生存时间与脑转移发生时间有明显影响；治疗以全脑加局部治疗最佳。[关键词]乳腺癌脑转移预后放疗CjClinicalcharacterof103patientswithBrainmetastasisofbreastcancerShenGe,SongSan-Tai,Ji
3、angZe-Fei,WuShi-Kai,WangTao,ZhangShao-Hua,LuXin-You,ZengMin,HuangHong-Yan,DingLi-Juan,DuMeng.(CancercenteroftheaffiliatedhospitaltoAcademyofMilitaryMedica1Science,Beijing100071,China.)[Abstract]BackgroundandPurpose:Breastcancer/dSscommonandoftenleadstomortal
4、ity.Brainmetastasisofbreastcancerisdifficulttocureevenotherlocalitiesareundercontrol.Wecollectedclinicaldataonpatientswithbrainmetastasisofbreastcancerandexploredclinicalcharacteristicsoftheconditionthatwereassociatedwiththeoutcomesurvivaltime.Methods:Wecoll
5、ecteddatain103patientsdisease-freesurvivaltime,timetobrainmetastasis,lymphestrogen/progesteroneandher-2receptorexpression,treatments,afterradiationtherapy.Wedescribedclinica1characteristicsofexploredfactorsthatwereassociatedwithsurvival.Results:Thewithbrainm
6、etastasisofbreastcancerfrom>August1978toNovember2008,includingnodemetastasis,andsurvivaltimethesepatientsandmedianageforthediagnosiswas45(range:10.l-65.9).Estrogenand/orprogesteronereceptorstatus,thenumberofpositivelymphnodes,radiotherapymethods,andthenumbe
7、rofbrainmetastasiswereassociatedwithsurviva1times,includingdisease-freesurvivaltime,timefromdiagnosistobrainmetastasis,survivaltimeafterbrainmetastasis,andtotalsurvivaltime,albei^Miotsignificantinallcases.Conclusion:Estrogen/Progesteronereceptornegativityand
8、numbersofpositivelymphnodesandbrainmetastasisindicateadverseprognosisandcombinationofwholeandlocalbrainradiotherapyimprovespatients，survivaltimeafterbrainmetastasis.prognosis,radiotherapy[Keywor
