凉血解毒法治疗血小板减少性紫癜临床对照研究

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1、地黄止血胶囊治疗儿童难治性特发性血小板减少性紫瘢临床研究河北省石家庄平安医院血液科石家庄市博士血液病研究所(石家庄050021)刘清池吴维海武大勇冯新旺马亚辉李建英庞宇慧宋淑花摘要:目的以环他菌素A作对照，观察凉血解毒小药地黄止血胶囊治疗儿童慢性特发性血小板减少性紫瘢(RITP)的临床疗效。方法41例儿童RITP病人随机分为中药组21例,对照组20例，中药组服用地黄止血胶囊，2〜3粒，每口三次；对照组用环泡菌素A3mg/kg/U，两组均以治疗三个刀为一个疗程。统计疗效，观察毒副反应。结果地黄止血胶

2、0121例，有效14例(66.7%),坏抱菌索A组20例，可供疗效统计17例，有效8例(47.1%);两组对比总有效率有显著差别(PV0.05)。治疗8周后，地黄止血胶囊组出血症状改善明显好于对照组(PV0.05)。地黄止血胶囊组无明显毒副作用，而对照组出现多毛症15例，牙龈增生10例，胃肠道反应5例，肝功能损害5例，高血压2例，肾功能损害2例。结论凉血解毒屮药地黄止血胶囊治疗儿童CITP疗效优于环砲菌素A,且无明显毒副反应，治疗顺从性好。关键词：血小板减少性紫瘢原发性屮药凉血解毒治疗Clinic

3、alStudyonDihuangZhixueCapsuleinTreatmentofchildrenwithrefractoryidiopathicthrombocytopenicpurpura*LIUQingchi,WUWeihai^WUDayong^etal.DepartmentofHematologyyShijiazhuangPing"anHospital,hebei,Shijiazhucmg050021Abstract:ObjectiveToobservetherapeuticeffect

4、ofDihuangZhixueCapsulecontrasttocyclosporinA(CsA)onchildrenwithrefractoryidiopathicthrombocytopenicpurpura(RITP).Methods41childrenofRITPwererandomlydividedinto2groups.DihuangZhixueCapsulegroup(21patients)wastreatedwithChineseherbsDihuangZhixueCapsule,

5、2-3Capsules,ticl;CsAgroup(20patients)wastreatedwithCsA,3mg•kg•d•Thepatientstreatedfullyonecourseof6monthsweresentintostatisticsanalysis.Toestimatetheeffectandtheadverseevents.ResultsTheeffectiverateinDihuangZhixueCapsulegroupwas66.7%(14/21),andCsAgrou

6、pwas47.1%in17patientsmaybeevaluated.Thecontrastoftwogroupswasmarked(P<0.05).Aftereightweeks,thesymptomofhemorrhagewasmoreremissiveinDihuangZhixueCapsulegroupthaninCsAgroup(Pv().()5).NoadverseeventshappenedinDihuangZhixueCapsulegroup,butadverseeventswa

7、smoreinCsAgroup,15casesofhirsutismJOcasesgumhyperplasia,5casesofgastrointestinalreactions^casesofliverdamage,2casesofhypertensionand2casesofrenaldysfunction.ConclusionComparetheeffectDihuangZhixueCapsulegroupwasmoreeffectivethanCsAgroup.Noadverseevent

8、sandBettertreatmentcomplianceinDihuangZhixueCapsulegroup.Keywords:idiopathicthrombocytopenicpurpuraChineseherbs/therapeuticuse儿童慢性特发性血小板减少性紫瘢(RITP)山急性特发性血小板减少性紫瘢发展而來，対糖皮质激索反应差，是一种常见的血液系统疾病，以各种部位的反复岀血为主要临床表现，迁延难愈。西药有不少用环抱菌素A治疗RITP有效的报道我们从2004年5