凉血解毒膏治疗急性ⅱ-ⅲ级放射性皮炎的临床研究

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1、授予单位代码10089学号或申请号13626HebeiMedicalUniversity硕士学位论文在职科学学位凉血解毒膏治疗急性II-III级放射性皮炎的临床研究研究生：高静导师：李晶主任医师专业：中西医结合临床二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，

2、试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。年Jr月丨&日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写,文责自负。目录中文摘要·············································································1英文摘要·············

3、································································3研究论文凉血解毒膏治疗急性II-III级放射性皮炎的临床研究前言·············································································6材料与方法····································································6结果···········

4、··································································13附表·············································································15讨论·············································································20结论······························

5、···············································24参考文献·······································································25综述放射性皮肤粘膜损伤防治进展·········································27致谢············································································

6、·······41个人简历·············································································42中文摘要凉血解毒膏治疗急性II-III级放射性皮炎的临床研究摘要恶性肿瘤是严重危害人类健康的疾病，放射治疗是目前恶性肿瘤治疗的重要手段之一，通过放疗可有效提高手术的局部控制率及远期生存率。但放射线除对肿瘤细胞有杀伤作用以外，还会损伤到正常组织，尤其是皮肤组织，放射性皮肤损伤发生率高达91.4%，放射性皮肤损伤在放疗过程中常常不可避免，因此

7、放疗患者皮肤反应的预防和处理是否及时得当，关系到放疗过程的顺利实施及患者生活质量和远期预后。目前临床治疗放射性皮肤粘膜损伤药物品种较多，方法各异，主要以外用药物为主，西药外用药物多为国外进口，作用单一，价格昂贵，中药具有抗炎、清热、止痛、促修复等多重治疗作用，且价格低廉。本研究是运用中医外治法治疗急性放射性皮肤损伤的临床研究，目的在于减轻患者痛苦与放射线对皮肤的损伤，保证放疗方案的顺利实施。目的：凉血解毒膏治疗头颈部及胸壁恶性肿瘤，并在治疗期间发生急性Ⅱ级、Ⅲ级放射性皮肤损伤的随机对照临床研究，观察其临床效果并评价安全

8、性，以期降低放射性皮肤粘膜的毒副反应，提高放射治疗的完整性及连续性。方法：本研究采取随机、对照、非盲的方法。严格按照本研究的病例纳入排除标准，选取2010年8月至2014年4月期间河北医科大学第四医院收治入院接受放射治疗的头颈部及胸壁恶性肿瘤，并在治疗期间发生急性Ⅱ级、Ⅲ级放射性皮肤损伤的患者。将入院后接受放射线治疗，在治疗过程中