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ID:42160852
大小:63.05 KB
页数:9页
时间:2019-09-09
《兔颈静脉动脉化后血管的重塑机制(医学论文)》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、兔颈静脉动脉化后血管的重塑机制作者:陶登顺,王辉山,汪曾炜,朱洪玉,高文根,王建生,杨丽君【关键词】静脉移植;细胞凋亡;模型,动物Mechanismofvascularremodelingafterrabbitjugularveingraitarterialization[Abstract]AIM:Toestablisharabbitmodelofcarotidarterialvenousbridgebypassgraitandobservethepathologicalchangeoftheveinbridgeatdifferentphases,todetecttheex
2、pressionsofPCNAandaactin,cellapoptosis,andtoinvestigatethemechanismofveingra仕remodeling.METHODS:Thecommoncarotidarteryandexternaljugularveinof30rabbitsweredissociatedandanastomosedsidebyside,sothatarterialbloodwentthroughexternaljugularveinbridge・Veinbridgesgetatdifferenttimepointsa仕eroper
3、ationwereanalyzedquantitativelyinregardtothethicknessofintimaandmedia,andobservedintheexpressionsofPCNAandaactinandcellapoptosis・RESULTS:Allrabbitssurvived・Theveinbridgekeptsmooth.Theintimaandmediaproliferatedobviously・Thewallofveingra仕thickened,buttheintimaproliferatedunequally,tothepeaki
4、n24weeks・TheexpressionofPCNAoccurredinbothintimaandmedia,whiletheexpressionofaactinoccurredonlyinintima・Cellapoptosisoccurred1weekalteroperationinintimaandmediaandpeakeduntil4weeks・CONCLUSION:Rabbitjugularveinaftercarotidarterialvenousbridgebypassgraftshowedanunirregularincreaseinthewallth
5、ickness・Proliferationoccurredattheearlystagemainlyinintima・Proliferationofsmoothmusclecellsinmediaandtheirmigrationintointima,cellapoptosismayallparticipateinveingra仕remodeling.[Keywords]venousgraft;apoptosis;models,animal【摘要】目的:建立兔颈动脉静脉桥旁路移植模型,观察不同时期静脉桥病理改变及PCNA,aactin表达和检测细胞凋亡,探讨移植静脉重塑机制
6、.方法:家兔30只,将一侧颈总动脉与颈外静脉分别游离后,行颈总动脉与颈外静脉侧侧吻合,结扎颈外静脉两吻合口外侧及颈总动脉吻合口中部,使动脉血经颈外静脉桥通过,于术后不同时间段取静脉桥行HE及弹力纤维染色,定量分析血管壁内膜、中膜厚度,观察PCNA,aactin表达和细胞凋亡情况.结果:30只家兔全部存活,静脉桥全部保持通畅;病理所见静脉桥血管壁增厚、血管内膜及中膜均明显增生,术后2-4wk内膜增生达高峰,且厚度不均匀,中膜、内膜均有PCNA阳性表达,内膜出现aactin阳性表达,术后1wk血管内膜及中膜开始出现凋亡细胞,术后4wk达高峰.结论:兔颈静脉动脉化后静脉血管管壁呈
7、不均一性增厚,早期以血管内膜增生为主,中膜血管平滑肌细胞增殖并向内膜迁移,细胞凋亡可能参与血管桥重塑.【关键词】静脉移植;细胞凋亡;模型,动物0引言静脉血管作为血管桥材料在冠状动脉旁路移植术中具有重要作用,但血管的再狭窄一直是困扰静脉移植的难题,影响冠状动脉旁路移植术的近远期疗效.为了研究静脉血管动脉化后的改变,我们建立了兔颈动脉静脉旁路移植模型,对静脉血管移植于动脉后不同时间段的病理改变进行观察,通过血管壁PCNA,aactin表达和细胞凋亡的检测,初步探讨静脉血管重塑的机制.1材料和方法1.1材料健康家兔36只
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