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1、Lecture9 AnalysisofSurvivalDataOutlineIntroductionBasicParametricModelsEstimationComparisonofGroupsSummaryandConclusions2
2、BasicStatisticsinClinicalTrials
3、IISChina
4、AnalysisofSurvivalData
5、AllRightsReservedLearningObjectivesUnderstandsurvivaldata(生存数据)and
6、itsspecialfeatures,inparticularnon-normalityandcensoring(删失)Knowhowtoperformbasicsurvivaltime(生存时间)analyses,includingKaplan-Meierplotsandlog-ranktestsBeabletoapplythebasicmethodstoreal-worldproblems3
7、BasicStatisticsinClinicalTrials
8、IISChina
9、AnalysisofS
10、urvivalData
11、AllRightsReservedIntroductionCOPDCaseStudyBasicConceptsBasicParametricModelsEstimationComparisonofGroupsSummaryandConclusions4
12、BasicStatisticsinClinicalTrials
13、IISChina
14、AnalysisofSurvivalData
15、AllRightsReservedCOPDStudyExampleBackgroundDesign
16、:double-blind,parallel-groupstudytoassessanewdrugAinpatientswithChronicObstructivePulmonaryDisease(COPD,慢性阻塞性肺病)48patientswererandomizedtoeitherdrugAorplaceboat1:1ratio25patientsreceiveddrugA;23patientsreceivedplaceboPatientswerefollowedupto52weeksObje
17、ctive:comparethetimetofirstexacerbation(病情加重)betweentwotreatmentgroups(newdrugAversusplacebo)5
18、BasicStatisticsinClinicalTrials
19、IISChina
20、AnalysisofSurvivalData
21、AllRightsReservedCOPDStudyExampleDataStructureCensor(删失):ifpatienthasnothadtheeventatthetimeo
22、fanalysisDataareamixtureofcensoredanduncensoredobservationsPIDGroupEventCensoringSurvivaltime(inweeks)1DrugYESNO83DrugNOYES126DrugNOYES52...............2PlaceboYESNO154PlaceboNOYES445PlaceboNOYES2...............PID=Patientidentification6
23、BasicStatistic
24、sinClinicalTrials
25、IISChina
26、AnalysisofSurvivalData
27、AllRightsReservedCOPDStudyExampleBoxplotsThesurvivaltimesarenotnormallydistributedHowtoanalyzethedata?9
28、BasicStatisticsinClinicalTrials
29、IISChina
30、AnalysisofSurvivalData
31、AllRightsReservedSurvivalDataSpeci
32、alFeaturesSurvivaldataareusuallycontinuous,butoftenhighlyskewed(偏斜的,偏态的)andnon-normalObservationsmaybecensoredEventmaynotbeobservedforsomepatientsatthetimeofanalysisSomepatientsmaydropoutinthemiddleofthestudyandallweknowaboutthemisthela
