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1、HumanPathology(2016)49,49–53www.elsevier.com/locate/humpathOriginalcontributionCXCR4overexpressioncorrelateswithpoorprognosis☆,☆☆inmyastheniagravis–associatedthymomaWeiWangMD,PhD,DazhongLiuMD,PhD,LeiYangMD,PhD,YiLiMD,HaoXuMD,FeiWangMD,JiayingZhaoMD,LinyouZhangMD,PhD⁎DepartmentofThoraci
2、cSurgery,SecondAffiliatedHospitalofHarbinMedicalUniversity,Harbin150086,ChinaReceived22July2015;revised5October2015;accepted8October2015Keywords:SummaryThymomais1raretypeoftumordevelopedonthethymicepithelium;patientswiththymomaThymoma;alsomighthavemyastheniagravis(MG).Becauseofthescarc
3、ityandcomplexityofMG-associatedMyastheniagravis;thymoma,itspathogenesisandetiologystillremainunclearnowadays.TheexpressionofC-X-CCXCR4;chemokinereceptortype4(CXCR4)isabsentorlowinmosthealthytissuesbuthighlyexpressedinPrognosis;varioustypesoftumors.Here,todeterminetheprognosticsignifica
4、nceofCXCR4inMG-associatedSurvivalthymoma,atotalof84tissuesampleswereretrospectivelyexamined.OurdatademonstratedthatCXCR4wasstronglyassociatedwithworseoverallsurvival(hazardratio,2.11;95%confidenceinterval,1.08-4.11)anddisease-freesurvival(hazardratio,1.84;95%confidenceinterval,1.03-3.2
5、9).Furthermore,bothunivariateandmultivariateanalysesconfirmedthatCXCR4wasanindependentfactorinpredictingunfavorableoverallsurvival.Inconclusion,ourfindingssuggestthatCXCR4mightcontributetotheclinicalcancerprogression,andCXCR4couldbeavaluableprognosticbiomarkerinthetherapyofMG-associate
6、dthymoma.©2015ElsevierInc.Allrightsreserved.1.Introductionautoimmunediseaseofneuromuscularjunctionmediatedprimarilybyanti–acetylcholinereceptorantibodies.Thy-momaMGisbelievedtoaccountfor10%to30%ofallMGThymomais1primarymediastinalneoplasmarisingfromcases[3].Althoughgreatprogresshasbeena
7、chievedintheepithelialcellsinthethymus,thecentralorganofthepastseveraldecades,theexactpathologicmechanismsofimmunesystem.ItisreportedthattheincidenceofthymomaMG-associatedthymomaarestillpoorlyunderstood.There-is0.15per100000personseveryyearintheUnitedStatesfore,itisofgreatvaluetoiden
