资源描述：
《Protein tyrosine phosphatases from genes, to function, to disease》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、REVIEWSProteintyrosinephosphatases:fromgenes,tofunction,todiseaseNicholasK.TonksAbstract
2、Theproteintyrosinephosphatase(PTP)superfamilyofenzymesfunctionsinacoordinatedmannerwithproteintyrosinekinasestocontrolsignallingpathwaysthatunderlieabroadspectrumoffundamentalphysiologic
3、alprocesses.Inthisreview,IdescriberecentbreakthroughsinourunderstandingoftheroleofthePTPsintheregulationofsignaltransductionandtheaetiologyofhumandisease.Inthiseraof‘omics’researchthathasfollowedthesignaltransduction.Attentionhasbeendrawnrecentlysequencingofthehumangenome,fa
4、miliesofsignallingtohaloaciddehalogenases,whichincludephosphatasesmoleculesarebeingdefinedandthecomplexitiesofthesuchasEyesabsent(Eya),whichalsofunctionsasatrans-regulationofsignaltransductionarenowbecomingcriptionfactor4,andchronophin,whichisaregulatorofapparent.Incontrastt
5、oinitialviewsofsignallingpath-cofilinphosphorylationand,thereby,affectsthedyna-waysassimplelineararrangementsofphosphorylationmicsoftheactincytoskeleton5.Theseenzymescatalysecascadesthatfunctioninisolation,itisnowclearthatdephosphorylationthroughanunusualmechanismthattherear
6、emultipleinteractingsignallingnetworks,theinvolvesessentialasparticacidresiduesattheactivesite.coordinationofwhichinresponsetoastimulusdeter-Variousphosphatasesalsoregulatesignaltransductionminesphysiologicaloutcome.Theimportanceofphos-througheffectsonnon-proteinsubstrates,i
7、ncludingSrcphorylationandtheregulatoryroleofproteinkinaseshomology-2(SH2)-domain-containinginositidephos-isestablished;however,ithasrecentlybecomeappar-phatases(SHIPs)andsynaptojanins,whichcatalysetheentthatproteinphosphatasescannolongerbevieweddephosphorylationofinositolpho
8、spholipids6.aspassivehousekeepingenzymesintheseprocesses.Inthisreview,Ifocusontheproteintyrosinephos-Instead,thekinasesandphosphatasesarepartners,phatases(PTPs),whichareencodedbythelargestfamilyandtheiractivitiesarecoordinatedintheregulationofofphosphatasegenes.Theseenzymesa
9、redefinedbythesignallingresponses.Thedistinctbutcomplementaryactive-sitesig
