protein_stucture_and_function__primers_in_biology_

《protein_stucture_and_function__primers_in_biology_》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、1FromSequencetoStructureThegenomicsrevolutionisprovidinggenesequencesinexponentiallyincreasingnumbers.Convertingthissequenceinformationintofunctionalinformationforthegeneproductscodedbythesesequencesisthechallengeforpost-genomicbiology.Thefirststepinth

2、isprocesswilloftenbetheinterpretationofaproteinsequenceintermsofthethree-dimensionalstructureintowhichitfolds.Thischaptersummarizesthebasicconceptsthatunderlietherelationshipbetweensequenceandstructureandprovidesanoverviewofthearchitectureofproteins.1-

3、0Overview:ProteinFunctionandArchitecture1-1AminoAcids1-2GenesandProteins1-3ThePeptideBond1-4BondsthatStabilizeFoldedProteins1-5ImportanceandDeterminantsofSecondaryStructure1-6PropertiesoftheAlphaHelix1-7PropertiesoftheBetaSheet1-8PredictionofSecondaryS

4、tructure1-9Folding1-10TertiaryStructure1-11MembraneProteinStructure1-12ProteinStability:WeakInteractionsandFlexibility1-13ProteinStability:Post-TranslationalModifications1-14TheProteinDomain1-15TheUniverseofProteinStructures1-16ProteinMotifs1-17AlphaDo

5、mainsandBetaDomains1-18Alpha/Beta,Alpha+BetaandCross-LinkedDomains1-19QuaternaryStructure:GeneralPrinciples1-20QuaternaryStructure:IntermolecularInterfaces1-21QuaternaryStructure:Geometry1-22ProteinFlexibility1-0Overview:ProteinFunctionandArchitectureB

6、indingTATAbindingproteinMyoglobinSpecificrecognitionofothermoleculesiscentraltoproteinfunction.Themoleculethatisbound(theligand)canbeassmallastheoxygenmoleculethatcoordinatestothehemegroupofmyoglobin,oraslargeasthespecificDNAsequence(calledtheTATAbox)t

7、hatisboundanddistortedbytheTATAbindingprotein.Specificbindingisgovernedbyshapecomplementarityandpolarinteractionssuchashydrogenbonding.TheTATAbindingproteinbindsaspecificMyoglobinbindsamoleculeofoxygenDNAsequenceandservesastheplatformreversiblytotheiro

8、natominitshemeforacomplexthatinitiatestranscriptionofgroup(showningreywiththeironingeneticinformation.(PDB1tgh)green).Itstoresoxygenforuseinmuscletissues.(PDB1a6k)CatalysisDNApolymeraseHIVproteaseEssentiallyeverychemicalreactionintheliv