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ID:31609707
大小:6.88 MB
页数:174页
时间:2019-01-15
《protein_stucture_and_function__primers_in_biology_》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、1FromSequencetoStructureThegenomicsrevolutionisprovidinggenesequencesinexponentiallyincreasingnumbers.Convertingthissequenceinformationintofunctionalinformationforthegeneproductscodedbythesesequencesisthechallengeforpost-genomicbiology.Thefirststepinth
2、isprocesswilloftenbetheinterpretationofaproteinsequenceintermsofthethree-dimensionalstructureintowhichitfolds.Thischaptersummarizesthebasicconceptsthatunderlietherelationshipbetweensequenceandstructureandprovidesanoverviewofthearchitectureofproteins.1-
3、0Overview:ProteinFunctionandArchitecture1-1AminoAcids1-2GenesandProteins1-3ThePeptideBond1-4BondsthatStabilizeFoldedProteins1-5ImportanceandDeterminantsofSecondaryStructure1-6PropertiesoftheAlphaHelix1-7PropertiesoftheBetaSheet1-8PredictionofSecondaryS
4、tructure1-9Folding1-10TertiaryStructure1-11MembraneProteinStructure1-12ProteinStability:WeakInteractionsandFlexibility1-13ProteinStability:Post-TranslationalModifications1-14TheProteinDomain1-15TheUniverseofProteinStructures1-16ProteinMotifs1-17AlphaDo
5、mainsandBetaDomains1-18Alpha/Beta,Alpha+BetaandCross-LinkedDomains1-19QuaternaryStructure:GeneralPrinciples1-20QuaternaryStructure:IntermolecularInterfaces1-21QuaternaryStructure:Geometry1-22ProteinFlexibility1-0Overview:ProteinFunctionandArchitectureB
6、indingTATAbindingproteinMyoglobinSpecificrecognitionofothermoleculesiscentraltoproteinfunction.Themoleculethatisbound(theligand)canbeassmallastheoxygenmoleculethatcoordinatestothehemegroupofmyoglobin,oraslargeasthespecificDNAsequence(calledtheTATAbox)t
7、hatisboundanddistortedbytheTATAbindingprotein.Specificbindingisgovernedbyshapecomplementarityandpolarinteractionssuchashydrogenbonding.TheTATAbindingproteinbindsaspecificMyoglobinbindsamoleculeofoxygenDNAsequenceandservesastheplatformreversiblytotheiro
8、natominitshemeforacomplexthatinitiatestranscriptionofgroup(showningreywiththeironingeneticinformation.(PDB1tgh)green).Itstoresoxygenforuseinmuscletissues.(PDB1a6k)CatalysisDNApolymeraseHIVproteaseEssentiallyeverychemicalreactionintheliv
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