Influence of Dietary Protein on Renal Function in Dogs

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1、DietandRenalFailureInfluenceofDietaryProteinonRenalFunctioninDogs1KEHHETHC.BOVÉE2SchoolofVeterinaryMedicine,UniversityofPennsylvania,Philadelphia,PA19104treatmentofnaturallyoccurringrenalfailureinanimalssimilartothosedescribedinhumans.CompletionDownloaded

2、fromABSTRACTTwopreviouslypublishedstudiesindogswithreducedrenalfunctionarereviewed.Inthefirstofsuchastudywouldbeextremelydifficultandexstudy,renalfunctionandbiochemicalresponsestodipensiveandwouldfaceevenmoreseverelimitationsetarychangeswerestudiedinfourdo

3、gswithstablethanthoseencounteredbythecurrentmulticenterchronicrenalfailure.Theobjectivewastodetermineifdogswithmoderatestablefailureadjusttodietswithstudyinhumanmedicine.Therefore,presentdataarevariedproteinandelectrolytecontent.Thesedogsweregeneratedfrome

4、xperimentalmodelsthathaveprovenjn.nutrition.orgfoundtohavethecapacitytoadapttoawiderangeofusefultoelucidatethemechanismsofuremiaindogsdietaryproteinandelectrolyteintake.Theonlyexcepandrats(1).tionwasfoundindogsfedareduced-proteindiet,whichTerminology.These

5、termsaregenerallyusedinfailedtoappropriatelyadjustrenaltubularexcretionofsodiumandphosphate.TheonlyadvantageofreducednephrologytodescribethevariousstagesofreducedatNEWYORKUNIVERSITYBOBSTLIBRARYonSeptember8,2016dietaryproteininthisstudywasareductioninbloodk

6、idneyfunction:reducedrenalmass,permanentlossureanitrogen(BUN).Disadvantagesofreduced-proteinofamajorportionofrenaltissue,usuallyquantifieddietswerereducedglomerularfiltrationrate(GFR)andbyreductioninglomerularfiltrationrate(GFR);renalrenalplasmaflow.Inthes

7、econdstudy,thehypothesisthatlargeamountsofdietaryproteinsustainrenalhy-insufficiency,reductionofrenalfunctionintheabperfunctionandproduceprogressiveglomerulosclero-senceofclinicalsignswithmildazotemiaornoabsisindogsaspreviouslyreportedinratswastested.norma

8、litiesinstandardclinicalchemistrymeasuresResultsfailedtofindapatternofdeteriorationofrenal(reductioninfunctionmayrangeupto60%lossoffunctionover4y.LightmicroscopicchangesandelecGFR);progressionofrenalfailure,g