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1、Vol.6,2175±2182,June2000ClinicalCancerResearch2175AdvanvesinBriefPrimingTissue-specificCellularImmunityinaPhaseITrialof1AutologousDendriticCellsforProstateCancerPatrickA.Burch,JamiK.Breen,aftertwooreventhreeinjectionsofPA2024,showingthatJanC.Buckner,DennisA.
2、Gastineau,directlyinjectedPA2024wasinvolvedinstimulationofhumoralimmunity.DendriticcellsexposedtoantigenexJudithA.Kaur,ReinerL.Laus,vivocaninduceantigen-specificcellularimmunityinpros-DouglasJ.Padley,MadhusudanV.Peshwa,tatecancerpatients,warrantingfurtherstu
3、diesofthismodeHenryC.Pitot,RonaldL.Richardson,ofimmunotherapy.BouwienJ.Smits,PitsataSopapan,GeorgeStrang,FrankH.Valone,andIntroductionStanimirVuk-PavlovicÂ2Adenocarcinomaoftheprostateisthemostcommonma-DivisionsofMedicalOncology[P.A.B.,J.C.B.,J.A.K.,H.C.P.,li
4、gnancyinAmericanmenandthesecondmostfrequentcauseR.L.R.],TransfusionMedicine[D.A.G.,D.J.P.],andStemCelloftheirdeathfromcancer;nearly40,000menareprojectedtoLaboratory[S.V-P.],MayoClinicandMayoFoundation,Rochester,diefromthisdiseasein1999(1).Forpatientswithadva
5、ncedMinnesota55905,andDendreonCorporation,Seattle,Washingtondisease,standardcareincludeshormoneablationbybilateral98121[R.L.L.,M.V.P.,B.J.S.,P.S.,G.S.,F.H.V.]orchiectomyorbyagonistsofluteinizinghormone-releasinghormone,withorwithoutantiandrogens(2).Initially
6、,mostAbstractpatientsrespondtothistreatment,butinmorethanonehalfthediseasebecomesrefractorytohormonetherapyin,2years(2).WeattemptedtoinducetherapeuticimmunityagainstThetreatmentofhormone-refractorydiseaseislessthansatis-prostate-derivedtissuesinpatientssuffe
7、ringfromprogres-factory.Treatmentoptionsincludesupportivecareonly:second-sivehormone-refractorymetastaticprostatecarcinoma.linehormonaltherapy(e.g.,addingorwithdrawingantiandro-Thirteenpatientsweretreatedwithtwoinfusions,1monthgens,corticosteroids,andothers)
8、;chemotherapy;and/orapart,ofautologousdendriticcells(APC8015)preexposedexperimentaltreatments(3).Nonetheless,themediansurvivalexvivotoPA2024,afusionproteinconsistingofhumanofpatientssufferingfro
