Single-cell dynamics determines response to CDK46 inhibition in triple negative breast cancer.[2017][Clin Cancer Res][10.11581078-0432.ccr-17-0369]

《Single-cell dynamics determines response to CDK46 inhibition in triple negative breast cancer.[2017][Clin Cancer Res][10.11581078-0432.ccr-17-0369]》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、PublishedOnlineFirstJune12,2017;DOI:10.1158/1078-0432.CCR-17-0369Asgharetal.ClinicalCancerResearchTitle:Single-celldynamicsdeterminesresponsetoCDK4/6inhibitionintriplenegativebreastcancerAuthors:12111UzmaS.Asghar,AlexisR.Barr,RosCutts,MatthewBeaney,IrinaBabina,Deepak33333Sampat

2、h,JenniferGiltnane,JenniferArcaLacap,LisaCrocker,AmyYoung,Alex1121,4Pearson,MariaTeresaHerrera-Abreu,ChrisBakalandNicholasC.Turner.Affiliations:1BreastCancerNowTobyRobinsResearchCentre,InstituteofCancerResearch,London,SW36JB,UK.2TheDivisionofCancerBiology,InstituteofCancerResea

3、rch,London,SW36JB,UK.3Genentech,DepartmentofTranslationalOncology,Genentech(RocheGroup),SouthSanFrancisco,U.S.A.4BreastUnit,TheRoyalMarsdenHospital,FulhamRoad,London,SW36JJ,UK.Runningtitle:CDK4/6inhibitionintriplenegativebreastcancerKeywords:Triplenegativebreastcancer,CDK4/6inh

4、ibitors,CDK2activity,CyclinEFinancialSupport:ThisresearchwasfundedbytheAvonfoundation(U.S.Asghar),BreastCancerNowwithgeneroussupportfromtheMary-JeanMitchellGreenFoundationandCancerResearchUKC30746/A16642(N.C.Turner).TheauthorsalsoacknowledgeNHSfundingtotheNIHRBiomedicalResearch

5、CentreatTheRoyalMarsdenandtheICR.Correspondingauthor:NicholasC.TurnerInstituteofCancerResearchandRoyalMarsdenHospital237FulhamRoad,London,SW36JB,UK,Tel+442073528133Email:nicholas.turner@icr.ac.ukPage1of28Downloadedfromclincancerres.aacrjournals.orgonJune17,2017.©2017AmericanAss

6、ociationforCancerResearch.PublishedOnlineFirstJune12,2017;DOI:10.1158/1078-0432.CCR-17-0369Asgharetal.ClinicalCancerResearchTranslationalrelevance:Currentlytherearenoeffectivetargetedtherapiesfortriplenegativebreastcancer(TNBC).WeshowthattheLuminalAndrogenReceptorsubtypeofTNBCi

7、shighlysensitivetoCDK4/6inhibitionwhilstbasal-likeTNBCtumoursareresistant.DifferentialsensitivityofTNBCsubtypestoCDK4/6inhibitionisshowntobearesultofcellsexitingmitosisintoanactiveproliferatingoraquiescentstate.Basal-likeTNBCshaveahighproportionofactiveproliferatingcellsthatare

8、resistanttoCDK4/6inhibition,whichispromotedbydysregula