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1、BreastCancerResTreatDOI10.1007/s10549-015-3611-0PRECLINICALSTUDYDevelopmentoftriple-negativebreastcancerradiosensitivegenesignatureandvalidationbasedontranscriptomeanalysis1,31,32,31,3AlimujiangWushou•Yi-ZhouJiang•JingHou•Yi-RongLiu•2,31,3Xiao-MaoGuo•Zhi-MingShaoReceive
2、d:22September2015/Accepted:14October2015ÓSpringerScience+BusinessMediaNewYork2015AbstractTriple-negativebreastcancer(TNBC)isapatients.Twogenesignaturesspecificallyidentifiedaheterogeneousdiseasewithhighestloco-regionalrecur-radiosensitivepopulationthathadanimprovedrecurre
3、nce-renceamongbreastcancersubtypes.Radiotherapyisfreesurvivalinpatientstreatedwithsurgeryradio-indispensableforTNBCloco-regionalcontrol.However,chemotherapy(RadiosensitivepatientsvsradioresistantintrinsicradiosensitivitydifferencesexistinTNBCpatientspatients,forseven-ge
4、neRSGS:P=0.024,HR=0.35,andRTisstillprescribedmainlybasedonconventional95%CI0.14–0.87andforthree-geneRSGS:P=0.035,clinicopathologicfeaturesofpatientswithoutconsideringHR=0.38,95%CI0.15–0.94).Incontrast,therewasnothedifferences.Thepurposeofthepresentstudyistosignificantdif
5、ferenceinoutcomebetweenpredicteddevelopandvalidateaTNBCradiosensitivegenesignatureradiosensitiveandradioresistantpatientsthattreatedwith(RSGS)andtoguidetherapeuticdecisions.Inthisstudy,othertreatmentmodality.RSGSsprovideausefultoolforwecomparedtranscriptomeprofilesof12lo
6、callyrecurrentidentificationofradiosensitive/radioresistantTNBCTNBCsto20non-locallyrecurrentTNBCstreatedwithpatientsandtheycouldleadtoabetterselectionofpatientssurgeryradio-chemotherapyanddevelopedaseven-geneforRTprotocols.RSGSandasimplifiedthree-geneRSGSbyusingpathwayana
7、lysis,univariateCoxproportionalhazardsregressionKeywordsTriple-negativebreastcancerTranscriptomemodelandrank-basedlinearalgorithm.Theywerevali-analysisRadiosensitivegenesignaturedatedbyusingtranscriptomeprofilesof166TNBCBackgroundElectronicsupplementarymaterialTheonlin
8、eversionofthisBreastcancer(BC)isthemostcommoncancerdiagnosedarticle(doi:10.1007/s10549-015-3611-0)containssupp
