dairy consumption and risk of breast cancer：a meta-analysis of prospective cohort studies

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1、BreastCancerResTreat(2011)127:23–31DOI10.1007/s10549-011-1467-5REVIEWDairyconsumptionandriskofbreastcancer:ameta-analysisofprospectivecohortstudiesJia-YiDong•LijunZhang•KaHe•Li-QiangQinReceived:10February2011/Accepted:17March2011/Publishedonline:27March2011ÓSpringerScience+BusinessMedia,LLC.201

2、1AbstractEpidemiologicfindingsareinconsistentregardinglow-fatdairyintakethanforhigh-fatdairyintakeandforriskforbreastcancerrelatedtodairyconsumption.Wepremenopausalwomenthanforpostmenopausalwomen.performedameta-analysisofprospectivecohortstudiestoTherewasasignificantdose–responserelationshipoftot

3、alexaminetheassociationbetweendiaryproductconsump-dairyfood,butnotmilk,consumptionwithbreastcancertionandriskofbreastcancer.APubMeddatabasesearchrisk.Littleevidenceofpublicationbiaswasobserved.InthroughJanuary2011wasperformedforrelevantstudies.conclusion,findingsofthepresentmeta-analysisindicate

4、Weincludedprospectivecohortstudiesthatreportedrela-thatincreasedconsumptionoftotaldairyfood,butnottiveriskswith95%confidenceintervalsfortheassociationmilk,maybeassociatedwithareducedriskofbreastofdairyconsumptionandbreastcancerrisk.Arandomcancer.effectsmodelwasusedtocalculatethesummaryriskestima

5、tes.Weidentified18prospectivecohortstudieseli-KeywordsDairyproducts
Milk
Breastcancer
gibleforanalysis,involving24,187casesand1,063,471Cohortstudies
Meta-analysisparticipants.Thesummaryrelativeriskofbreastcancerforthehighestintakeoftotaldairyfoodcomparedwiththelowestwas0.85(95%confidenceinterval:

6、0.76–0.95),withIntroduction2evidenceofheterogeneity(P=0.01,I=54.5%).Formilkconsumption,thesummaryrelativeriskwas0.91Breastcanceristhemostcommoncancerandthesecond(95%confidenceinterval:0.80–1.02),andsubstantialhet-leadingcauseofdeathwithrespecttocanceramongwomenin2UnitedStates[1].Therecentanalysi

7、sbytheNationalInstituteserogeneitywasobserved(P=0.003,I=59.7%).Sub-groupanalysesbasedonlimitednumbersofstudiesofHealthhasshowedthatthenationalmedicalcostofbreastsuggestedthattheassociationsweresomewhatstrongerforcancercareisestima