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1、Menopause:TheJournalofTheNorthAmericanMenopauseSocietyVol.22,No.10,pp.000/000DOI:10.1097/gme.0000000000000440*2015byTheNorthAmericanMenopauseSocietyPrognosticimpactofchemotherapy-inducedamenorrheaonpremenopausalbreastcancer:ameta-analysisoftheliterature1,2,32,32,3,42,3QiongZhou,MM
2、,WenjinYin,MD,YueyaoDu,MD,ZhenzhouShen,MD,2,3,4andJingsongLu,MDAbstractObjective:Weconductedthismeta-analysisofpublisheddatatoassesstheexactprognosticvalueofadjuvantchemotherapy-inducedamenorrhea(CIA)asaprognosticfactorforpremenopausalbreastcancer.Methods:Wesearchedforallrelevants
3、tudiespublishedbeforeMay2014inthePubMed,OVID,andEMBASEdatabases.Relativerisks(RRs)wereusedtoestimatetheassociationbetweenCIAandvarioussurvivaloutcomes,includingdisease-freesurvival(DFS)andoverallsurvival(OS).Results:Thismeta-analysisidentified13eligiblestudiesincluding5,513casesan
4、d2,008controlsforDFSand5eligiblestudiesincluding2,331casesand776controlsforOS.ResultsdemonstratedthatCIAisassociatedwithimprovedDFS(RR,0.67;95%CI,0.61-0.74;PG0.001)andOS(RR,0.60;95%CI,0.50-0.72;PG0.001).Insubgroupanalyses,CIAwasfoundtoaffectDFS(RR,0.73;95%CI,0.61-0.88;P=0.001)ines
5、trogenreceptor(ER)Ypositivepatients;however,similarresultswerenotobservedinER-negativepatients(forDFS:RR,0.97;95%CI,0.66-1.41;P=0.858).ParticipantswithCIAachievedasignificantlybetterprognosisthanparticipantswithoutCIA,irrespectiveofnodalstatus,chemotherapyregimen,endocrinetherapy,
6、orpublicationyear.Conclusions:Thismeta-analysisclarifiesthatCIAcontributestoimprovedprognosisinpremenopausalwomenwithER-positivebreastcancerandisatleastpartiallyresponsibleforthebenefitsofadjuvantchemotherapyinthesewomen,whichinducechemicalcastration.KeyWords:Chemotherapy-induceda
7、menorrheaYBreastneoplasmYPrognosisYMeta-analysis.djuvantchemotherapyandendocrinetherapyhavewomen.Itisnotclearwhetherchemotherapy-inducedamen-beenconfirmedtoincreasesurvivalandtoreducetheorrhea(CIA)impactsprognosisorismerelyamarkeroftheA1<3riskofrecurrenceofbreastcancer.Interesting
8、ly,innegativeeffectsofchemotherap
