高血压英文ppt精品课件prospective cohort

《高血压英文ppt精品课件prospective cohort 》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、FrederickL.Brancati,MD,MHSProfessorofMedicine&EpidemiologyDirector,DivisionofGeneralInternalMedicineOslerJournalClub2006VisitHopkinsGIMathttp://www.hopkinsmedicine.org/gimProspectiveCohortStudiesBackgroundPhysicalactivitylowerCVDriskDHHSrecommendslife-longpursuitsSportsdifferinsustainabil

2、ityCVDbenefitsofindividualsportsuncertainTheJohnsHopkinsPrecursorsStudyOver1300students(mainlywhitemen)fromtheJHUSOMClassesof1948-64.Baselinedatacollectedinpersoninmedicalschool.Follow-updatacollectedbyyearlymailedquestionnairesthereafter.CarolineThomas,MDTheJohnsHopkinsPrecursorsStudyHypo

3、thesis:TennisabilityinyouthpredictslowerCVDriskinmiddleageDesign:ProspectivecohortstudySetting:JohnsHopkinsPrecursorsStudyParticipants:1019malemedicalstudentsDataCollection:Extensiveinterviewandphysicalassessmentatbaseline(early20s);annualmailedfollow-upquestionnairesOutcome:IncidentCVD,in

4、cludingMI,CHD,CABGorPTCA,hypertensiveheartdisease,heartfailure,&cerebrovasculardiseaseAnalysis:Kaplan-Meier,CoxmodelsOutlineAssessmentofSportsAbilityHowwouldyourateyouroverallabilityintennis(golf,football,baseball,basketball)duringandbeforemedicalschool?NoabilityPoororfairabilityGoodorexce

5、llentabilityNodataonfrequency,intensity,orsubsequentparticipationResultsConclusions/ImplicationsSelf-describedtennisabilityinyoungadulthoodpredictslowerCVDriskinmiddleageAssociationoftennistolowerriskisGraded(i.e.dose-response)IndependentofmanypossibleconfoundersSpecifictotennis(ashypothes

6、ized)SuggestspromotionoftennisasameanstoreduceCVDriskStrengthsProspectivedesignLong-termfollow-upMultiavariateanalysisBlindedassessmentofCVDWeaknessesObservationalstudiescan’tprovecausalityResidualconfoundingislikelyAssessmentofexposurewassuboptimalAbility,notactivitySinglepoint,notrepeate

7、dmeasuresSelf-assessed,notobjectiveSamplelimitsgeneralizabilityDiscussionPointsWhat’sspecialaboutacohortstudy?Whatarecommonobstacles?Canitbeusedforhousestaffresearch?Caniteverbesufficienttochangepractice?Howdocohortstudiesrelatetooutcomesresearch?TaxonomyofDes