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1、BloodVesselsFrankA.Acevedo,PA-CVascularAbnormalitiesNarrowingofthelumenThrombosisWeakeningofthewallsNormalIntima-EndothelialCellsMedia-SmoothMuscleCellsAdventitia-ConnectiveTissueArteriesElasticarteriesMusculararteriesArteriolesEndotheliumAnticoagulant/Antithromboticprostacycli
2、n,thrombomodulin,plasminogenactivator,heparin-likemoleculesProthromboticVonWillebrandFactor,tissuefactor,plasminogenactivatorinhibitorVascularSmoothMuscleVasoconstrictionDilatationCollagen,elastinsynthesisCellularproliferationinatherosclerosisVascularDiseasesCongenitalanomalies
3、AtherosclerosisHypertensivevasculardiseaseThevasculitidesRaynaud’sdiseaseAneurysmsVasculartumorsCongenitalAnomaliesBerryaneurysmsAVfistulasAtherosclerosisElasticandmediumsizedarteriesAtheromaisthebasiclesionAge,male,geneticLDL,VLDLMonocytes-macrophages-foamcellsEndothelialinjur
4、yAtherosclerosisAtherosclerosisAtherosclerosisAtherosclerosisRiskFactorsMajordietandhyperlipidemia,hypertension,cigarettesmoking,diabetesMinorobesity,lackofexercise,age,male,familyhistory,stress,BCP,HighCHOintake,hyperhomocysteinemiaHypertensionIdiopathic,essentialRenin-Angiote
5、nsinAcceleratedatherogenesisHyalineatherosclerosisVasculitidesGiantcellarteritisTakayasu’sarteritisPolyarteritisnodosaKawasakidiseaseWegener’sgranulomatosisBuerger’sdiseaseGiantCellArteritisRarebeforeage50ThrobbingpainVisualdisturbancesTemporalarteryCorticosteroidsPolymyalgiarh
6、eumaticaGiantCellArteritisGiantCellArteritisTakayasu’sArteritisFibrousthickeningofaorticarchUpperextremitypulselessnessFemales15-40PolyarteritisNodosaSystemicinvolvementFever,weightloss,hypertensionAbdominalpainMelenaMuscleachesMotorperipheralneuropathyPolyarteritisNodosaKawasa
7、kiSyndromeYoungchildrenandinfantsFever,conjunctivalandoralerythemaanderosion,edemaofthehandsandfeet,erythemaofthepalmsandsoles,desquamation,lymphnodeenlargementLeadingcauseofacquiredheartdiseaseinchildrenWegener’sGranulomatosisAcutenecrotizinggranulomasoftheupperandlowerreaptra
8、ctFocalnecrotizingvasculitisRenaldisease5thdecadeoflif
