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1、Burkitt’sLymphoma:Clin【关键词】Burkitt’s,lymphoma,#8226;,Immunophenotype,#8226;,c-myc,#8226;,Oute,#8226;,Differential,diagnosis LEARNINGOBJECTIVES Afterpletingthiscourse,thereaderphomaandthediscoveryofitsassociationphoma,includingtheclinicalandpathologicalvariantsofthislymphoma. Discu
2、ssthetreatmentstrategiesusedfortreatingBurkitt’slymphoma. ListthecriteriaforestablishingadiagnosisofBurkitt’slymphomaanddiscusstheentitiesthatmayenteritsdifferentialdiagnosis. ABSTRACT Burkitt’slymphomaisahighlyaggressivelymphomaidentifiedanddescribedinthelastcenturybyDenisBurkitt
3、inAfrica,inareasendemicformalaria.SinceitsdescriptioninAfricanchildren,ithasbeenrecognizedoutsideareasicmalaria,frequentlyalsoinchildrenasongindividualsmunodeficiency.SinceitsinitialdesignationasBurkitt’slymphoma,thistypeoflymphomaandlymphomascloselyresemblingithavereceivedavarietyof
4、namesindifferentclassificationsoflymphomasandleukemias:undifferentiatedlymphoma,Burkitt’sandnon-Burkitt’stypeinthemodifiedRappaportClassification,malignantlymphoma,smallnon-cleavedcell,Burkitt’stypeintheulation,Burkitt’slymphomaandhigh-gradeB-celllymphoma,Burkitt-likeintheREALClassif
5、ication,andacutelymphoblasticleukemia,L3typeintheFABClassification.atopoieticandLymphoidTumors,thenomenclatureofthislymphomahasefullcircle,anditisonceagainknoplyasBurkitt’slymphoma.Inrecentyears,effortshavefocusedonimprovingtherapyforthisrapidlyproliferatingneoplasminimizing,totheext
6、entpossible,treatment-associatedtoxicity.Theseeffortshaveledtothedevelopmentofhigh-intensity,short-durationbinationchemotherapythathasprovenextremelyeffectiveforahighproportionofBurkitt’slymphomapatients.ThedifferentialdiagnosisofBurkitt’slymphomaisbroad,andprecisediagnosisbasedonhis
7、tologic,immunophenotypic,andgeicfeaturesremainsthecriticalfirststepinplanningappropriatetherapy. HISTORICALBACKGROUND Inthemiddleofthelastcentury,pala,henotedchildrenetimesacpaniedbyproptosis.Henotedthatsomechildrenhadhugeabdominalmasses,sometimesacpaniedbydiseaseinthefacialbones,a
8、lthoughthere
