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《Am J Clin Nutr-2016-Schleicher-ajcn.115.127985》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、AJCN.FirstpublishedaheadofprintJuly6,2016asdoi:10.3945/ajcn.115.127985.ThevitaminDstatusoftheUSpopulationfrom1988to2010usingstandardizedserumconcentrationsof25-hydroxyvitaminDshows1–3recentmodestincreases44565RosemaryLSchleicher,MayaRSternberg,DavidALacher,C
2、hristopherTSempos,AnneCLooker,66444RamonADurazo-Arvizu,ElizabethAYetley,MadhulikaChaudhary-Webb,KhinLMaw,ChristineMPfeiffer,*and5CliffordLJohnson456NationalCenterforEnvironmentalHealthandtheNationalCenterforHealthStatistics,CDC,Atlanta,GA;andtheOfficeofDietar
3、ySupplements,NIH,Bethesda,MDABSTRACTNHANESswereconductedperiodically.In1999,theNHANESBackground:TemporaltrendsintheUSpopulation’svitaminDwasredesignedtobecomeacontinuoussurvey;dataarereleasedstatushavebeenuncertainbecauseofnonstandardizedserumforevery2-ysurv
4、eycycle.VitaminDstatusassessmenthasbeen25-hydroxyvitaminD[25(OH)D]measurements.includedsinceNHANESIII(1988–1994)(1).Serumconcen-Objective:ToaccuratelyassessvitaminDstatustrendsamongthosetrationsof25-hydroxyvitaminD[25(OH)D]7metabolites,whichaged$12y,weusedda
5、tafromthecross-sectionalNHANESs.aretheprimarybiomarkersofstatus,arerelativelylong-lastingDesign:Aliquidchromatography–tandemmassspectrometry(LC-MS/indicatorsofvitaminDintakefromfoodsandsupplements,andMS)methodformeasuring25(OH)D(sumof25-hydroxyvitaminD2frome
6、ndogenouslyproducedvitaminDthroughtheactionofand25-hydroxyvitaminD3),calibratedtostandardreferencematerials,UV-Blightonskin.wasusedtopredictLC-MS/MS–equivalentconcentrationsfromradio-TheCDClaboratoryattheNationalCenterforEnvironmentalimmunoassaydata(1988–200
7、6surveys;n=38,700)andtomeasureHealthmeasuredtotal25(OH)DforNHANESsthatwerecon-LC-MS/MSconcentrations(2007–2010surveys;n=12,446).Weightedductedfrom1988through2006byusingaradioimmunoassay.arithmeticmeansandtheprevalenceof25(OH)DaboveorbelowcutoffAssaydifferenc
8、esduetoradioimmunoassayreformulationbe-concentrationswerecalculatedtoevaluatelong-termtrends.tweenNHANESIII(thelastperiodicsurvey)andNHANESResults:Overall,meanpredicted25(OH)Dshowednotimetrend20
