Am J Clin Nutr-2012-Tang-ajcn.111.030775[1]

《Am J Clin Nutr-2012-Tang-ajcn.111.030775[1]》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、AJCN.FirstpublishedaheadofprintAugust1,2012asdoi:10.3945/ajcn.111.030775.b-CaroteneinGoldenRiceisasgoodasb-caroteneinoilatproviding1–4vitaminAtochildrenGuangwenTang,YumingHu,Shi-anYin,YinWang,GerardEDallal,MichaelAGrusak,andRobertMRussellABSTRACTconsumptionhavebeensuggestedasrealisticandsustainab

2、leBackground:GoldenRice(GR)hasbeengeneticallyengineeredtoalternativestoovercomeVADglobally(10).However,theef-berichinb-caroteneforuseasasourceofvitaminA.ficacyofcarotenoid-richplantfoodsatpreventingVADhasObjective:TheobjectivewastocomparethevitaminAvalueofbeenshowntobelowerthanthatpreviouslyhopedf

3、ororex-b-caroteneinGRandinspinachwiththatofpureb-caroteneinoilpected:thevitaminAequivalencyofprovitaminAcarotenoidwhenconsumedbychildren.richfoodsvariesfrom2mgb-caroteneto1mgretinol(forDesign:Children(n=68;age68y)wererandomlyassignedtodietscontainingpureb-caroteneinoil)to27mgb-carotenetoconsumeGR

4、orspinach(bothgrowninanutrientsolutioncontain-1mgretinol(forb-caroteneincertainleafyvegetables)(1119).22ing23atom%H2O)or[H8]b-caroteneinanoilcapsule.TheGRMoreover,WHOreportspublishedin2009and2012claimthat2andspinachb-carotenewereenrichedwithdeuterium(H)withthew190250millionpreschoolchildrenworldw

5、idearestillaf-213highestabundancemolecularmass(M)atMb-C+H10.[C10]Ret-fectedbyVAD(3,20)andthatprovidingvitaminAsupplementsinylacetateinanoilcapsulewasadministeredasareferencedose.couldreduceall-causemortalityinchildrenyoungerthan5ybySerumsamplescollectedfromsubjectswereanalyzedbyusinggas2434%(4,5,

6、8).AUNICEFreportin2010(6)showedthatchromatographyelectron-capturenegativechemicalionizationmassabout8.1millionchildrenyoungerthan5ydiedin2009.Thus,spectrometryfortheenrichmentsoflabeledretinol:Mretinol+4(fromvitaminAavailabilityforallchildreninundernourishedsettings22[H8]b-caroteneinoil),Mretinol

7、+5(fromGRorspinach[H10]b-couldpreventw1.92.7millionchilddeathsannually.Inan13carotene),andMretinol+10(from[C10]retinylacetate).efforttoprovidelong-termandsustainablepreventionofVAD,13Results:Usingtheresponsetothedoseof