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1、REVIEWMultipotentialdifferentiationofadiposetissue-derivedstemcellsBrianMStrem,1,2KevinCHicok,1MinZhu,1IsabellaWulur,1ZeniAlfonso,1RondaESchreiber,1JohnKFraser1andMarcHHedrick1,21CytoriTherapeutics,Inc.,SanDiego,CA,USA2DepartmentsofSurgeryandBioengineering,UniversityofCalif
2、ornia,LosAngeles,CA,USA(ReceivedforpublicationonFebruary14,2005)(RevisedforpublicationonMay4,2005)(AcceptedforpublicationonMay19,2005)Abstract.Tissueengineeringoffersconsiderablepromiseintherepairorreplacementofdiseasedand/ordamagedtissues.Thecellularcomponentofthisregenera
3、tiveapproachwillplayakeyroleinbringingthesetissueengineeredconstructsfromthelaboratorybenchtotheclinicalbedside.However,theidealsourceofcellsstillremainsunclearandmaydifferdependingupontheapplication.Currentresearchformanyapplicationsisfocusedontheuseofadultstemcells.Thepro
4、pertiesofadultstemcellsthatmakethemwell-suitedforregenerativemedicineare(1)easeofharvestforautologoustransplantation,(2)highproliferationratesforexvivoexpansionand(3)multilineagedifferentiationcapacity.Thisreviewwillhighlighttheuseofadiposetissueasareservoirofadultstemcells
5、anddrawconclusionsbaseduponcomparisonswithbonemarrowstromalcells.(KeioJMed54(3):132–141,September2005)Keywords:adiposetissue-derivedstemcells,celldifferentiationIntroductionmyocardialischemia.2,3Likemarrow,adiposetissueisamesodermally-Whiteadiposetissuehastheabilitytodynami
6、callyderivedorganthatcontainsastromalpopulationcon-expandandshrinkthroughoutthelifeofanadult.Thistainingmicrovascularendothelialcells,smoothmusclecapacityismediatedbythepresenceofvascularandcellsandstemcells.4Thesecellscanbeenzymaticallynon-vascularcellsthatprovideapoolofst
7、emandpro-digestedoutofadiposetissue(commonlyfromlip-genitorcellswithuniqueregenerativecapacity.Thisoaspirate)andseparatedfromthebuoyantadipocytesreviewwilldescribetherecentpreclinicalresearchfo-bycentrifugation.Amorehomogeneouspopulationcusedonthesestemcellsandidentifypoten
8、tialclinicalemergesincultureunderconditionssupportiveofapplications.MSCgrowth.This
