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1、SupportingInformation©CopyrightWiley-VCHVerlagGmbH&Co.KGaA,69451Weinheim,2010SupportingInformationforGold(I)-CatalyzedCascadeforSynthesisofPyrrolo[1,2-a:2',1'-c]/Pyrido[2,1-c]pyrrolo[1,2-a]quinoxalinonesa,ca,b,caabaa,YuZhou,XunJi,GuannanLiu,DengyouZhang,LinxiangZhao,HualiangJiang
2、,andHongLiu*aTheCenterforDrugDiscoveryandDesign,StateKeyLaboratoryofDrugResearch,ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences,Shanghai,201203,ChinabSchoolofPharmaceuticalEngineering,ShenyangPharmaceuticalUniversity,Shenyang,Liaoning110016,ChinacTheseauthorscontribute
3、dequallytothisworkEmail:hliu@mail.shcnc.ac.cn.S1ContentsX-rayCrystallographicStructureof3La…………………………………………….…………S3GeneralInformation………………………………………………………………………………S5GeneralProcedureforGold-catalyzedTandemSynthesisofTargetCompounds……..…….S5CharacterizationDataforTargetCompounds………
4、…………………………………..………S5113CopiesofHNMRandCNMRofCompounds………………………………….……………S22S2N3LaNOFigureS1.X-raycrystallographicstructureof3La.S3TheDetailsofX-rayCrystallographicStructureof3LaBondprecision:C-C=0.0021AWavelength=0.71073Cell:a=13.0283(12)b=9.4485(8)c=22.978(2)alpha=90beta=90gamma
5、=90Temperature:293KCalculatedReportedVolume2828.5(4)2828.5(4)SpacegroupPbcaPbcaHallgroup-P2ac2ab?MoietyformulaC19H16N2O?SumformulaC19H16N2OC19H16N2OMr288.34288.34Dx,gcm-31.3541.354Z88Mu(mm-1)0.0850.085F0001216.01216.0F000'1216.46h,k,lmax16,11,2816,11,28Nref27832783Tmin,Tmax0.969,
6、0.9770.788,1.000Tmin'0.969Correctionmethod=EMPIRICALDatacompleteness=1.000Theta(max)=26.000R(reflections)=0.0439(2280)wR2(reflections)=0.1288(2783)S=1.033Npar=201CCDC761511containsthesupplementarycrystallographicdataforthispaper.ThesedatacanbealsoobtainedfreeofchargefromTheCambri
7、dgeCrystallographicDataCentreviawww.ccdc.cam.ac.uk/data_request/cif.S4GeneralInformationCommerciallyavailablereagentsandsolventswereusedwithoutfurtherpurification.Column113chromatographywascarriedoutonsilicagel.HandCNMRspectrawereobtainedonVarianMercury-300and/orVarianMercury-400
8、spectrometers(TMSasIS).Chemicalshiftswer
