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1、PreclinicalModelsforNeuroblastoma:EstablishingaBaselineforTreatment1.1,2.2,3222TalTeitz,JenniferJ.Stanke,SaraFederico,CoriL.Bradley,RachelBrennan,JiakunZhang,451467MelissaD.Johnson,JanSedlacik,MadokaInoue,ZiweiM.Zhang,SharonFrase,JeroldE.Rehg,5842,9,10ClaudiaM.Hillenbrand,DavidFinkelstein,
2、ChristopherCalabrese,MichaelA.Dyer*,JillM.1,11Lahti*1DepartmentofTumorCellBiology,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,2DepartmentofDevelopmentalNeurobiology,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,3DepartmentofHematolo
3、gy/Oncology,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,4AnimalImagingCenter,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,5DepartmentofRadiologicalSciences,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,6
4、CellandTissueImaging,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,7DepartmentofPathology,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,8InformationSciences,St.JudeChildren’sResearchHospital,Memphis,Tennessee,UnitedStatesofAmerica,9De
5、partmentofOphthalmology,UniversityofTennesseeHealthScienceCenter,Memphis,Tennessee,UnitedStatesofAmerica,10HowardHughesMedicalInstitute,ChevyChase,Maryland,UnitedStatesofAmerica,11DepartmentofMolecularSciences,UniversityofTennesseeHealthScienceCenter,Memphis,Tennessee,UnitedStatesofAmerica
6、AbstractBackground:Preclinicalmodelsofpediatriccancersareessentialfortestingnewchemotherapeuticcombinationsforclinicaltrials.ThemostwidelyusedgeneticmodelforpreclinicaltestingofneuroblastomaistheTH-MYCNmouse.Thisneuroblastoma-pronemouserecapitulatesmanyofthefeaturesofhumanneuroblastoma.Lim
7、itationsofthismodelincludethelowfrequencyofbonemarrowmetastasis,thelackofinformationonwhetherthegeneexpressionpatternsinthissystemparallelshumanneuroblastomas,therelativelyslowrateoftumorformationandvariabilityintumorpenetranceondifferentgeneticbackgrounds.Asa
