A Generic Framework for Non-rigid Registration Based on Non-uniform Multi-level Free-Form Deformation

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1、AGenericFrameworkforNon-rigidRegistrationBasedonNon-uniformMulti-levelFree-FormDeformationsJuliaA.Schnabel1,DanielRueckert2,MarcelQuist3,JaneM.Blackall1,AndyD.Castellano-Smith1,ThomasHartkens1,GraemeP.Penney1,WalterA.Hall4,HaiyingLiu5,CharlesL.Truwit5,FransA.Gerritsen3,Derek

2、L.G.Hill1,andDavidJ.Hawkes11ComputationalImagingScienceGroup,RadiologicalSciencesandMedicalEngineering,Guy’sHospital,King’sCollegeLondon,UKjulia.schnabel@kcl.ac.uk2VisualInformationProcessing,Dept.Computing,ImperialCollegeofScience,TechnologyandMedicine,London,UK3EasyVisionA

3、dvancedDevelopment,PhilipsMedicalSystems,Best,NL4Dept.Neurosurgery,UniversityofMinnesota,Minneapolis,MN,USA5Dept.Radiology,UniversityofMinnesota,Minneapolis,MN,USAAbstract.Thisworkpresentsaframeworkfornon-rigidregistrationwhichex-tendsandgeneralizesapreviouslydevelopedtechni

4、quebyRueckertetal.[1].Wecombinemulti-resolutionoptimizationwithfree-formdeformations(FFDs)basedonmulti-levelB-splinestosimulateanon-uniformcontrolpointdistribu-tion.Wehaveappliedthistoanumberofdifferentmedicalregistrationtaskstodemonstrateitswideapplicability,includinginterv

5、entionalMRIbraintissuedeformationcompensation,breathingmotioncompensationinliverMRI,intra-modalityinter-modalityregistrationofpre-operativebrainMRItoCTelectrodeimplantdata,andinter-subjectregistrationofbrainMRI.Ourresultsdemonstratethatthenewalgorithmcansuccessfullyregisteri

6、mageswithanimprovedperfor-mance,whileachievingasignificantreductioninrun-time.1IntroductionNon-rigidimageregistrationisplayinganincreasinglyimportantroleinbothclinicalandresearchapplications.Eventhoughthereisalargenumberofregistrationmethodstobefoundintheliterature[2,3],exist

7、ingmethodshaveusuallybeendesignedfororfine-tunedtospecific,mostlysingle-modalityapplications.Inthispaperweproposeaflexibleframeworkfornon-rigidregistrationwhichcoversarangeofdeformationtasksinmedicalapplications.Thisframeworkextendsandgeneralizesapreviouslypublishedmethodbasedo

8、nfree-formdeformations(FFDs)usingB-splineswhichwasdevelopedforregistrationo