2 Nonrigid registration using free-form deformations, application to breast MR images

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1、712IEEETRANSACTIONSONMEDICALIMAGING,VOL.18,NO.8,AUGUST1999NonrigidRegistrationUsingFree-FormDeformations:ApplicationtoBreastMRImagesD.Rueckert,*L.I.Sonoda,C.Hayes,D.L.G.Hill,M.O.Leach,andD.J.HawkesAbstractÐInthispaperwepresentanewapproachfortheyoungpremenopau

2、salwomenwithageneticpredispositionnonrigidregistrationofcontrast-enhancedbreastMRI.Ahierar-todevelopbreastcancer.chicaltransformationmodelofthemotionofthebreasthasbeenThishasledtotheinvestigationofalternativeimagingdeveloped.Theglobalmotionofthebreastismodele

3、dbyanmodalities,suchasMRI,forthedetectionanddiagnosisaffinetransformationwhilethelocalbreastmotionisdescribedbyafree-formdeformation(FFD)basedonB-splines.Normalizedofbreastcancer[2].EventhoughMRImammographyhasmutualinformationisusedasavoxel-basedsimilaritymeas

4、uredisadvantages,suchasalowspatialresolutionofaroundwhichisinsensitivetointensitychangesasaresultofthecontrast1mmandtheneedforcontrastagents,ithasanumberofenhancement.Registrationisachievedbyminimizingacostadvantages,includingthetomographic,andthereforethree-

5、function,whichrepresentsacombinationofthecostassociatedwiththesmoothnessofthetransformationandthecostassociateddimensional(3-D)nature,oftheimages.Thisallowsthewiththeimagesimilarity.ThealgorithmhasbeenappliedtoapplicationofMRImammographytobreastswithdensetiss

6、ue,thefullyautomatedregistrationofthree-dimensional(3-D)breastpostoperativescarring,andsiliconimplants.Furthermore,theMRIinvolunteersandpatients.Inparticular,wehavecomparedlackofradiationmakesitapplicabletoyoungpremenopausaltheresultsoftheproposednonrigidregi

7、strationalgorithmtowomen.Typically,thedetectionofbreastcancerinMRIthoseobtainedusingrigidandaffineregistrationtechniques.TheresultsclearlyindicatethatthenonrigidregistrationalgorithmisrequirestheinjectionofacontrastagentsuchasGadoliniummuchbetterabletorecovert

8、hemotionanddeformationoftheDTPA.Itisknownthatthecontrastagentuptakecurvesofbreastthanrigidoraffineregistrationalgorithms.malignantdiseasedifferfrombenigndiseaseandthispropertycanbeusedtoid