TISSUE FEATURE-BASED AND SEGMENTED DEFORMABLE IMAGE REGISTRATION

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1、Int.J.RadiationOncologyBiol.Phys.,Vol.74,No.4,pp.12561265,2009CopyrightÓ2009ElsevierInc.PrintedintheUSA.Allrightsreserved0360-3016/09/$seefrontmatterdoi:10.1016/j.ijrobp.2009.02.023PHYSICSCONTRIBUTIONTISSUEFEATURE-BASEDANDSEGMENTEDDEFORMABLEIMAGEREGISTRATIONFORIMPROVEDMODELI

2、NGOFSHEARMOVEMENTOFLUNGSyYAOQINXIE,PH.D.,*MINGCHAO,PH.D.,*ANDLEIXING,PH.D.**DepartmentofRadiationOncology,StanfordUniversitySchoolofMedicine,Stanford,CA;andyBeijingCityKeyLaboratoryofMedicalPhysicsandEngineering,PekingUniversity,Beijing,PeoplesRepublicofChinaPurpose:Toreport

3、atissuefeature-basedimageregistrationstrategywithexplicitinclusionofthedifferentialmo-tionsofthoracicstructures.MethodsandMaterials:Theproposedtechniquestartedwithauto-identificationofanumberofcorrespondingpointswithdistincttissuefeatures.Thetissuefeaturepointswerefoundbyusin

4、gthescale-invariantfeaturetrans-formmethod.Thecontrolpointpairswerethensortedintodifferent‘‘colors’’accordingtotheorgansinwhichtheyresidedandusedtomodeltheinvolvedorgansindividually.Athin-platesplinemethodwasusedtoregisterastructurecharacterizedbythecontrolpointswithagiven‘‘

5、color.’’Theproposedtechniquewasappliedtostudyadigitalphantomcaseand3lungand3livercancerpatients.Results:Forthephantomcase,acomparisonwiththeconventionalthin-platesplinemethodshowedthatthereg-istrationaccuracywasmarkedlyimprovedwhenthedifferentialmotionsofthelungandchestwallw

6、eretakenintoaccount.Onaverage,theregistrationerrorandstandarddeviationofthe15pointsagainsttheknowngroundtruthwerereducedfrom3.0to0.5mmandfrom1.5to0.2mm,respectively,whenthenewmethodwasused.Asimilarlevelofimprovementwasachievedfortheclinicalcases.Conclusion:Theresultsofourstu

7、dyhaveshownthatthesegmenteddeformableapproachprovidesanaturalandlogicalsolutiontomodelthediscontinuousorganmotionsandgreatlyimprovestheaccuracyandrobustnessofdeformableregistration.Ó2009ElsevierInc.Image-guidedradiotherapy,deformableimageregistration,segmentation.INTRODUCTIO

8、Nconsistofvarioustissues,suchasthetrachea,bronchia,andalveoli,whichcanhardl