阿尔茨海默病,诊断标记物,脑脊液3

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1、Downloadedfromhttp://jnnp.bmj.com/onNovember13,2015-Publishedbygroup.bmj.comResearchpaperCerebrospinalfluidbiomarkersinthedifferentialdiagnosisofAlzheimer’sdiseasefromothercorticaldementias1,2343LeonardoCruzdeSouza,FoudilLamari,SergeBelliard,ClaudeJardel,221,21,2Caroli

2、neHouillier,RaphaelDePaz,BrunoDubois,MarieSarazin

3、)candistinguishcontrolsfromAD(SD)andfrontotemporaldementia(FTD)patientsshowjournalonline(http://jnnp.bmj.123e8com).nopost-mortemAlzheimersdisease(AD)pathology,subjects,eveninearlystagesofthedisease.1cerebrospinalfluid(CSF)biomarkersmaybeofvalueforTheaccuracyofCSFbiomar

4、kersinthedifferentialCRICM,UPMCUnivParis06,distinguishingthesepatientsfromthosewithAD.diagnosisbetweenADandothercorticaldemen-Pitie´-Salpetrie`reHospital,Paris,FranceAdditionally,biomarkersmaybeusefulforidentifyingtias,however,isnotwellunderstood.Previous2AlzheimerIns

5、titute,ResearchpatientswithatypicalphenotypicpresentationsofAD,studieshaveprimarilyfocusedontheinterestinandResourceMemoryCentre,suchasposteriorcorticalatrophy(PCA)andprimarybiomarkerstodistinguishADfromfrontalvariantsCentredeRe´fe´rencedeprogressivenon-fluentorlogopen

6、icaphasia(PNFLA).offrontotemporallobardegenerations(FTLD),De´mencesRares,Pitie´-Salpetrie`reHospital,FranceMethodsTheauthorsinvestigatedCSFbiomarkerswhicharedefinedbybehaviouralchanges.These3(beta-amyloid1e42(Ab),totaltau(T-tau)andstudieshavefoundthatCSFbiomarkersareus

7、efulDepartmentofMetabolic42Biochemistry,Pitie´-Salpetrie`rephosphorylatedtau(P-tau))in164patientswithADindistinguishingADfromFTD,9e17andoneHospital,Paris,France(n¼60),PCA(n¼15),behaviouralvariantFTD(n¼27),study11demonstratedthehighsensitivityand4DepartmentofNeurology,

8、SD(n¼19),PNFLA(n¼26)andfunctionalcognitivespecificityofbiomarkersindistinguishingADfromCentreHospitalierRe´gionaletUniversita