肠上皮细胞功能

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1、Cell.Mol.LifeSci.(2012)69:2907–2917DOI10.1007/s00018-012-0984-7CellularandMolecularLifeSciencesREVIEWTheintestinalepitheliumtuftcells:specificationandfunctionFranc¸oisGerbe•CatherineLegraverend•PhilippeJayReceived:23February2012/Revised:21March2012/Accepted:26March2012/Pu

2、blishedonline:19April2012ÓTheAuthor(s)2012.ThisarticleispublishedwithopenaccessatSpringerlink.comAbstractTheintestinalepithelium,composedofatleastAbbreviationssevendifferentiatedcelltypes,representsanextraordinaryAc-tubulinAcetylatedtubulinmodeltounderstandthedetailsofmu

3、lti-lineagedifferen-Atoh1Atonalhomolog1tiation,aquestionthatishighlyrelevantindevelopmentalBrdU5-Bromo-20-deoxyuridinebiologyaswellasforclinicalapplications.ThisreviewCFTRCysticfibrosistransmembraneconductancefocusesonintestinalepithelialtuftcellsthathavebeenregulatorhomo

4、logacknowledgedasaseparateentityformorethan60yearsCK-18Cytokeratin18butwhosefunctionremainsamystery.WediscusswhatisDCLK1Doublecortin-likekinase1currentlyknownaboutthemolecularbasisoftuftcellfateDllDelta-likeanddifferentiationandwhyelucidatingtuftcellfunctionF-actinFibril

5、laractinhasbeensodifficult.Finally,wesummarizethecurrentGfi1Growthfactorindependent1hypothesesontheirpotentialinvolvementindiseasesoftheGfi1bGrowthfactorindependent1bgastro-intestinaltract.GIGastro-intestinalGIPGastricinhibitorypolypeptideKeywordsTuftcells
Brushcells
Intest

6、inalepithelium
GLP-1Glucagon-likepeptide1Atoh1
Celldifferentiation
Dclk1Hes1Hairyandenhancerofsplit1HpgdsHematopoieticprostaglandinDsynthaseKlf4Kruppel-likefactor4L-FABPFattyacid-bindingprotein1,liverLgr5Leucine-richrepeat-containingGprotein-coupledreceptor5F.Gerbe
C.Leg

7、raverend
P.JayNeurog3Neurogenin3CNRSUMR5203,34094Montpellier,FrancenNOSNitricoxidesynthase1,neuronalPGD2ProstaglandinD2F.Gerbe
C.Legraverend
P.JayINSERMU661,34094Montpellier,FrancePLCb2PhospholipaseC,Beta2PLCc2PhospholipaseC,Gamma2F.Gerbe
C.Legraverend
P.JayPtgsProstagla

8、ndin-endoperoxidesynthaseMontpellierIUniversity,34094Montpellier,FranceSox9SRY-boxcontaininggene9F.Gerb