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时间:2019-05-24
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1、Cell.Mol.LifeSci.(2012)69:2907–2917DOI10.1007/s00018-012-0984-7CellularandMolecularLifeSciencesREVIEWTheintestinalepitheliumtuftcells:specificationandfunctionFranc¸oisGerbe•CatherineLegraverend•PhilippeJayReceived:23February2012/Revised:21March2012/Accepted:26March2012/Pu
2、blishedonline:19April2012ÓTheAuthor(s)2012.ThisarticleispublishedwithopenaccessatSpringerlink.comAbstractTheintestinalepithelium,composedofatleastAbbreviationssevendifferentiatedcelltypes,representsanextraordinaryAc-tubulinAcetylatedtubulinmodeltounderstandthedetailsofmu
3、lti-lineagedifferen-Atoh1Atonalhomolog1tiation,aquestionthatishighlyrelevantindevelopmentalBrdU5-Bromo-20-deoxyuridinebiologyaswellasforclinicalapplications.ThisreviewCFTRCysticfibrosistransmembraneconductancefocusesonintestinalepithelialtuftcellsthathavebeenregulatorhomo
4、logacknowledgedasaseparateentityformorethan60yearsCK-18Cytokeratin18butwhosefunctionremainsamystery.WediscusswhatisDCLK1Doublecortin-likekinase1currentlyknownaboutthemolecularbasisoftuftcellfateDllDelta-likeanddifferentiationandwhyelucidatingtuftcellfunctionF-actinFibril
5、laractinhasbeensodifficult.Finally,wesummarizethecurrentGfi1Growthfactorindependent1hypothesesontheirpotentialinvolvementindiseasesoftheGfi1bGrowthfactorindependent1bgastro-intestinaltract.GIGastro-intestinalGIPGastricinhibitorypolypeptideKeywordsTuftcellsBrushcellsIntest
6、inalepitheliumGLP-1Glucagon-likepeptide1Atoh1CelldifferentiationDclk1Hes1Hairyandenhancerofsplit1HpgdsHematopoieticprostaglandinDsynthaseKlf4Kruppel-likefactor4L-FABPFattyacid-bindingprotein1,liverLgr5Leucine-richrepeat-containingGprotein-coupledreceptor5F.GerbeC.Leg
7、raverendP.JayNeurog3Neurogenin3CNRSUMR5203,34094Montpellier,FrancenNOSNitricoxidesynthase1,neuronalPGD2ProstaglandinD2F.GerbeC.LegraverendP.JayINSERMU661,34094Montpellier,FrancePLCb2PhospholipaseC,Beta2PLCc2PhospholipaseC,Gamma2F.GerbeC.LegraverendP.JayPtgsProstagla
8、ndin-endoperoxidesynthaseMontpellierIUniversity,34094Montpellier,FranceSox9SRY-boxcontaininggene9F.Gerb
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