垂体腺瘤侵袭性与MMP9、Ki67、nm23表达及MVD的相关性研究

《垂体腺瘤侵袭性与MMP9、Ki67、nm23表达及MVD的相关性研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、广西医科大学硕士学位论文垂体腺瘤侵袭性与MMP-9、Ki-67、nm23表达及MVD的相关性研究姓名：刘爱华申请学位级别：硕士专业：外科学指导教师：黄玮2003.1.1AstudyofcorrelationsbetweeninvasivenessofpituitaryadenomasandtheproteinexpressionofMMP-9，Ki'-67，rim23andmicrovesseldensity“uai．huaPostgraduateofMajorinSmge搿intheClassof2000，GuangxiMedicalUniversi哆NANNING530021(魏，

2、ANGXIAB鼹鬏ACTObjective：TostudytherelationshipbetweeninvasivenessofpituitaryadenomasandtheproteinexpressionsofMMP-9、Ki一67、nm23andmicrovesseldensityMethods：TheproteinexpressionsofMMP-9、Ki一67、nm23andmicrovesseldensityⅥ黼examinedbyimmunohistochemicalElivisionmethodsin78case,sofpituitaryadenomas。Ofthem

3、，羽CaSeSwithinvasivepituitaryadenomasand38CaSeSwithnoninvasivepituitaryadenomas．Results：TheexpressionsofMMP-9andKi-67ininvasivegroupWeresignificantlyhigherthanthoseinnoninvasivegroup(P硼．01)．Theexpressionofrim23ininvasivegroupwassignificantlylowerthanthatinnoninvasivegroup(P《O。01)，microvesseldensi

4、tyininvasivegroupwassignificantlyhigherthanthatinnoninvasivegroup(P<0．01)Meanwhile，theaverageMVDofMMP一9-positivewassignificantlyhigherthanthatinMMP一9一negativegroup(P

5、owerthanthatinnm23-negativegroup(P

6、andnm23maybeplayimportantrolesintheinvasivenessofpituitaryadenomas．MMP一9，Ki一67，nm23proteinandMVDmayprovidemolecularmarkersfordeterminingpimitaryadenomainvasiveness．ThedeletionsofMMP-9，Ki-67andnm23proteinandMVDareveryusefulfordinicalevaluationofinvasivenessandmanagementplansofpituitaryadenomas．Ke

7、ywords：PituitaryadenomaImmunohistochemistryInvasiveness垂体腺瘤侵袭性与瑚P一9、Ki一67、nm23表达及MVD的相关·胜研究刘袋华广嚣医辩大学2000缀井耪学研究生广嚣南宁53∞21摘要强的：搽讨垂体艨瘸孛MMP-9、Ki．67、rim23麴蛋自表达及CD34单抗标记的MVD和垂体腺瘸侵袭性毫塑堂缱遣的关系。方法：应用免疫组化Elivision法对78例垂体腺瘤MMP-9、Ki，67、n