消痞1号治疗功能性消化不良的疗效观察

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1、·中文论著摘要·消痞1号治疗功能性消化不良的疗效观察目的观察消痞1号改善胃动力治疗功能性消化不良的临床疗效及对胃排空功能的影响。方法将40例诊断为功能性消化不良患者随机分为两组，观察组给予消痞1号，对照组给予多潘立酮(西安杨森制药有限公司生产)10mg，3次／天，疗程均为4周。治疗前后分别进行症状评分，并用钡条．试餐法检测胃排空情况。结果两组治疗4周均可明显改善FD患者餐后饱胀不适、早饱、上腹痛、上腹烧灼感、暖气、恶心、上腹胀等症状，与治疗前相比，差异有显著性(P<0．05)；观察组治疗前症状总积分为12．1±2．75，治疗后为4．55±2．87

2、，差异有显著性(P

3、空率，有效率分别为85％和60％，与治疗前相比有显著差异(P

4、yingthroughimprovinggastricmotilityinthetreatmentoffunctionaldyspepsia．MethodFortypatientswithfunctionaldyspepsiawererandomizedinto2groups．XiaopiNo．1wasgiventotheobservationgroupand10mgDomperidone()(i’anJanssenPharmaceuticalLTD)3timesperdaytothecontrolgroupfor4weeks．Recordthe

5、scoresofthesymptoms，anddetecttheabilityofgastricemptyingbeforeandaftertreatmentbythemethodofeatingbariumstrip—trialmeal．ResultBothmedicalandcontrolgrouphavesignificantlyimprovedthesymptomsofabdominaldistention，earlysatiety，upperabdominalpain，heartburnandbelchinginpatientswith

6、functionaldyspepsia4weeksaftertreatment(P<0．01)．Thescoresofthesymptomsofmedicalgroupbeforeandafterthetreatmentwere12．1±2．75and4．55±2．87respectively(P<0．01)．Thescoresofthesymptomsofcontrolgroupbeforeandafterthetreatmentwere12．45±2．50and6．25±2．38respectively(P<0．01)．Theeffectiv

7、eratesinmedicalgroupontheabovesymptomswere63．2％，66．7％，83．9％，51．6％，54．2％，41．7％and28．6％respectively，whichhadstatisticaldifferencefromthatofcontrolgroup(28．9％，40％，36．4％，45．9％，72％，84．6％and57．1％respectively)．Observationandcontrolgrouphavealsoimprovedgastricemptyingratesinpatientsw

8、ithdelayedgastricemptying．andtheeffectiverateswere85％and60％respectiv