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1、厄贝沙坦与非洛地平联用对高血压病左室肥厚的逆转作用四川I【爰学2008年I2月第29卷(第12期)Sichtat[~ledicalJo;mI.2008,Vo1.29.No.12厄贝沙坦与非洛地平联用对高血压病左室肥厚的逆转作用刘亚辉,王挺,彭建(资中县人民医院,四川资中641200)论着【摘要】目的探讨厄贝沙坦与非洛地平联合用药对原发性高血压(EH)患者左室肥厚(LVH)的逆转作用.方法EH伴LVH患者6O例随机分为对照组(非洛地平5rag/d,30例)和治疗组(厄贝沙坦150mg/d加非洛地平5mg/d,30例),治疗2周时若血压仍>160/95mmHg(1mmHg
2、一0.133kPa),非洛地平分别增加l倍,总疗程共6个月.结果两组治疗后均能显着降低左室重量指数(LVMI)(P<0.01),且治疗组较对照组更为显着(P<0.O1);两组治疗前平均收缩压,平均舒张压比较无统计学意义(P>0.05),治疗后较治疗前显着降低(P<0.叭),但治疗后两组间无统计学意义(P>O.05).结论厄贝沙坦与非洛地平联用逆转EH患者LVH效果较单用非洛地平疗效更为显着.【关键词】高血压病;左心室肥厚;厄贝沙坦;非洛地平【中图分类号】R541.3【文献标识码】A【文章编号】1004—0501(2008)12—1624—02E
3、ffectofirbesartancombinedwithfelodipineoilreversingleftventricularhypertrophyinpatientswithessentialhyperten-sion.,J一^Ⅱ,WANGTing,PENGJian.ePeople'sHo~imlofZizhong.Z~hong.Sichuan,641200.China【Abstract】0MectiveTostudytheeffectsofirbesartanwithfelodipineonreversingleftventrielarhypertrophy(LV
4、H)inpatientwithessentialhypertension(EH).MethodsSixtypatientswithEHweredividedrandomlyintotwogroups:thecontrolledgroup(felodip—ine5mg/d.n=30)andthetreatmentgroup(irbesartan150mg/dwithfelodipine5mg/d.n=30).Ifthebloodpressure>160/95mmHgwasremainedaftertwosweekstherapy.thedosagewillbedoubl
5、edandthetherapywillbelastedfor6months.ResultsFollowingthera—pyfor6months,1efIventfieularmassindex(LVMI)decreasedsignificantlyinthetreatmentgroup(P<0.O1).LVMIinthetestgroupde—creasedmorethanthatinthecontrlledgroup(P<0.O1).Therewerenodiffereneesforthemeansystolicpressure(DBP)andmeandia
6、s—toliepressure(SBP)pre—therapyintwogroups【P>O.05).Followingtherapyfor6months.SBPandDBP/24hdecreasedsignificantly(P<0.01).buttherewerenodifferencebetweenthetwogroups(P>0.05).ConclusionTheresultssuggestthanirbesartancombinedwithfelodipineisabletoincreasetheeffectonreversingLVHinpat
7、ientswithEH.【Keywords】essentialhypertension;lefIventrieularhypertrophy:irbesartan:felodipine高血压病(EH)常伴发左心室肥厚(LVH),LVH是心血管疾病的独立危险因素,与心功能减退,室性心律失常,猝死密切相关,药物逆转LVH受到人们日益重视.血管紧张素II(AnglI)受体拮抗剂(ARB)在这方面的作用初步得到了肯定,钙通道阻断剂(CCB)对LVH的逆转作用已被大量的试验和临床研究所证实.ARB和CCB联合治疗,对EH所致
