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1、MaterialSciences材料科学,2013,3,110-115doi:10.12677/ms.2013.33021PublishedOnlineMay2013(http://www.hanspub.org/journal/ms.html)ReleasePerformanceinVitroofnHA/PLGAScaffoldsContainedwithProteinSustained-ReleasePLLAMicrospheresPreparedbyMeansofSupercriticalFluid*FoamingT
2、echnology#PeipeiLi,YanBai,GuangfuYinCollegeofMaterialsScienceandEngineering,SichuanUniversity,Chengdu#Email:nic0700@scu.edu.cnndththReceived:Mar.22,2013;revised:Mar.27,2013;accepted:Apr.19,2013Copyright©2013PeipeiLietal.Thisisanopenaccessarticledistributedunderthe
3、CreativeCommonsAttributionLicense,whichpermitsunre-stricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.Abstract:Inordertoconstructaboneregenerationsystemthatdifferentcellfactorscontrolledreleaseatproperstage,Trypsin(Try)wasse
4、lectedasthemodelprotein,andthecompositeofsustained-releasemicrospheresandbiodegradableporousscaffoldswaspreparedinthisstudy.Firstofall,Tryloadedpoly-l-lacticacidmicrospheres(Try-PLLAms)wereprepared,andthencompoundedtothenanohydroxyapatite/polylactic-co-glycolicaci
5、d(nHA/PLGA)tobuildascaf-foldthatcanreleasegrowthfactorssequentially.TheresultsshowedthattheTry-PLLAmsweresphericalshapewithdiametersof2-7μm.TheencapsulationefficiencyoftheTryinPLLAmswas80.5%,andtheloadingcapacitywas0.89%.ThepreparedTry-PLLAms/nHA/PLGAscaffoldposse
6、ssed150-300μmporediameter,50.9%-76.8%porosity,3.9-5.1MPacompressivestrength,and19.8%degradationat8weeks.ThecumulativereleasesofTryfromTry-nHA/PLGAscaffoldsandfromTry-PLLAmswererespectivelyabout85%and65.2%at48hours,andthatfromTry-PLLAms/nHA/PLGAscaffoldswere32.9%at
7、48hoursand60.6%at21days.TheresultsdemonstratedthatTry-PLLAms/nHA/PLGAscaffoldshadexcellentdrugreleaseperformancewithsuitablecompressivestrength,whichwouldbeusedastissueengineeringscaffoldswithproteindelivery.Keywords:PolyLactic-Co-GlycolicAcid;Poly-L-LacticAcid;Dr
8、ugLoadedMicrospheres;TissueEngineeringScaffolds;SupercriticalFluidFoamingTechnique超临界流体发泡技术制备含PLLA缓释微球nHA/PLGA*复合支架及体外释放性能研究#李培培，白燕，尹光福四川大学材料科学与工程学院，成都#
