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ID:36530805
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页数:28页
时间:2019-05-11
《C型利钠肽在慢性阻塞性肺疾病、肺心病中的变化及临床意义》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、遵义医学院硕士学位论文C型利钠肽在慢性阻塞性肺疾病、肺心病中的变化及临床意义姓名:王留新申请学位级别:硕士专业:呼吸内科指导教师:杨渝浩2003.5.17磋圭磅究盎拳整凳交C型测钠肷在慢性阻塞性肺疾病、慢性肺源性心脏病中鹣交傀及赣瘴意义摘要鲻的探讨C型利钠肽(e艘)在慢性烈塞性肺疾嫡(chronicobstructivepulmonarydisease,COPD)、慢性肺源性心脏瘸(简称肺心病,chroniccotpulmonale,cop)孛藩绺惩襄羲露豢曳。菇法慕穗羧凳蘧蛰潮28例慢性支气管炎急
2、性期并戳塞瞧肺气肿(A组)、30例肺心病急瞧期<鹣躯)粕缓黼湖(&缀),30铡健康对烈壤(e鳃)静瓤漩中熬CNP、鬻上爨髓爱豢(ADM),彀演中懿盎警交嶷生长鞭子(¥阱F)采爆簿袋免疫吸防法(ELISA)溺崽。结果矗、致耘8撞i盘浆CNP帮AO:;I及血瀚VEGF水平均赢于C缌(p<0。01):成浆CNP水平疆高于遥§<氇05),魏鑫予A缀《p<疆§1);盎装ADM零t擎&蠢予篷
O。os):斑清VEOF水平B:岗予‰和A组(p3、捡戆嚣(p>O,05)。扶A缉到BnBI,盘蘩瀚与鼗渣¥端F,建装A隧寒乎稳童受甏美(分嶷凳r=O。698,p4、疆塞性肺源蛙心皴病血管内皮生长因予。{。硕士研竞盎毕业论文Changesandclinicalsignificanceofplasmac-typenatriureticpeptidelevelsinpatientswithchronicobstructivepulmonarydiseaseandchroniccotpulmonaleAbstractO切ectiveTostudytheroleandclinicalsignificanceofplasmac—typenatriureticpeptide5、(CNP)levelsinpatientswithchronicobstructivepulmonarydisease(COPD)andchroniccorpulmonale,(cc秘.MethodClIPandadrenomedullin(ADS)ofPlasmasamplesfrom28patientsofchronicbronchitiswithobstructivepulmonaryemphysema(GroupA),30acuteexacerbation(GroupB1)andstable6、(GroupB2)ofCCPand30healthycontrol(GroupC)weredetectedbyradioimmoassagMeanwhile,serumlevelsofvascularendothelialgrowthfactor(VZGF)weretestedbyELISA.ResultLevelsofplasmaC№andADMandserumVEGFingroupBl,BEandgroupAweresignificantlyelevatedthanthatofcontrolgr7、oup(p8、cdifference(p>0.os).SerumVEGFingroupBlwassignificantlyhigherthanthatingroupB2(p<0。01).WhilebetweengroupB2andgroupA,therewasnostatisticdifference(p>O.05).DuringtheprocessfromAtoB2,andtoB1,levelsofplasmaCNPpositivelycorrelatedwiththatofSe
3、捡戆嚣(p>O,05)。扶A缉到BnBI,盘蘩瀚与鼗渣¥端F,建装A隧寒乎稳童受甏美(分嶷凳r=O。698,p4、疆塞性肺源蛙心皴病血管内皮生长因予。{。硕士研竞盎毕业论文Changesandclinicalsignificanceofplasmac-typenatriureticpeptidelevelsinpatientswithchronicobstructivepulmonarydiseaseandchroniccotpulmonaleAbstractO切ectiveTostudytheroleandclinicalsignificanceofplasmac—typenatriureticpeptide5、(CNP)levelsinpatientswithchronicobstructivepulmonarydisease(COPD)andchroniccorpulmonale,(cc秘.MethodClIPandadrenomedullin(ADS)ofPlasmasamplesfrom28patientsofchronicbronchitiswithobstructivepulmonaryemphysema(GroupA),30acuteexacerbation(GroupB1)andstable6、(GroupB2)ofCCPand30healthycontrol(GroupC)weredetectedbyradioimmoassagMeanwhile,serumlevelsofvascularendothelialgrowthfactor(VZGF)weretestedbyELISA.ResultLevelsofplasmaC№andADMandserumVEGFingroupBl,BEandgroupAweresignificantlyelevatedthanthatofcontrolgr7、oup(p8、cdifference(p>0.os).SerumVEGFingroupBlwassignificantlyhigherthanthatingroupB2(p<0。01).WhilebetweengroupB2andgroupA,therewasnostatisticdifference(p>O.05).DuringtheprocessfromAtoB2,andtoB1,levelsofplasmaCNPpositivelycorrelatedwiththatofSe
4、疆塞性肺源蛙心皴病血管内皮生长因予。{。硕士研竞盎毕业论文Changesandclinicalsignificanceofplasmac-typenatriureticpeptidelevelsinpatientswithchronicobstructivepulmonarydiseaseandchroniccotpulmonaleAbstractO切ectiveTostudytheroleandclinicalsignificanceofplasmac—typenatriureticpeptide
5、(CNP)levelsinpatientswithchronicobstructivepulmonarydisease(COPD)andchroniccorpulmonale,(cc秘.MethodClIPandadrenomedullin(ADS)ofPlasmasamplesfrom28patientsofchronicbronchitiswithobstructivepulmonaryemphysema(GroupA),30acuteexacerbation(GroupB1)andstable
6、(GroupB2)ofCCPand30healthycontrol(GroupC)weredetectedbyradioimmoassagMeanwhile,serumlevelsofvascularendothelialgrowthfactor(VZGF)weretestedbyELISA.ResultLevelsofplasmaC№andADMandserumVEGFingroupBl,BEandgroupAweresignificantlyelevatedthanthatofcontrolgr
7、oup(p8、cdifference(p>0.os).SerumVEGFingroupBlwassignificantlyhigherthanthatingroupB2(p<0。01).WhilebetweengroupB2andgroupA,therewasnostatisticdifference(p>O.05).DuringtheprocessfromAtoB2,andtoB1,levelsofplasmaCNPpositivelycorrelatedwiththatofSe
8、cdifference(p>0.os).SerumVEGFingroupBlwassignificantlyhigherthanthatingroupB2(p<0。01).WhilebetweengroupB2andgroupA,therewasnostatisticdifference(p>O.05).DuringtheprocessfromAtoB2,andtoB1,levelsofplasmaCNPpositivelycorrelatedwiththatofSe
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