klotho蛋白、caspase12蛋白在糖尿病肾病中的表达及意义

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1、授予单位代码10089学号或申请号G14001HebeiMedicalUniversity硕士学位论文在职科学学位klotho蛋白、Caspasel2蛋白在糖尿病肾病中的表达及意义学位申请人：常贯超导师：赵松教授专业：病理学与病理生理学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获得的研宄成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的

2、论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名导师签章二级学院领导盖章河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研宄成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研宄生签名导师签章:y月”日目录中文摘要·················································

3、····························1英文摘要·············································································4研究论文Klotho蛋白、Caspase12蛋白在糖尿病肾病中的表达及意义前言·············································································8材料与方法························

4、············································9结果·············································································13附图·············································································15附表················································

5、·····························22讨论·············································································23结论·············································································25参考文献····························································

6、···········25综述Klotho基因的研究进展··················································28致谢···················································································42个人简历·············································································43中文摘要Klo

7、tho蛋白、Caspase12蛋白在糖尿病肾病中的表达及意义摘要糖尿病已成为全球性疾病，在世界人口死亡原因中位居第五位。糖尿病肾病是糖尿病最常见的并发症之一，愈来愈威胁着糖尿病患者的生存，成为终末期肾功能衰竭的主要原因之一。糖尿病肾病的发病机制极其复杂，是多种因素综合作用的结果，其中，肾小管上皮细胞微环境改变，多种刺激因子出现，是导致原来发育成熟的肾小管上皮细胞的损伤，发生死亡，从而出现大量蛋白尿的重要原因之一。Klotho(Kl)基因是Kuro-o等在1997年研究自发性高血压时发现的与衰老有关的基因，Kl

8、otho基因表达的蛋白在人和鼠均有膜结合型和分泌型两种形式,其中分泌型的表达量明显高于膜结合型，是其主要的活化形式。分泌型Klotho蛋白在抗衰老、抗氧化应激、易化离子通道方面发挥着重要的激素样作用。Klotho主要在肾脏和脑脉络膜中表达，尤以在肾皮质小管上皮细胞表达最强。Klotho在肾脏的高表达决定了其在肾脏疾病发生发展中可能发挥着特殊作用。内质网应激是细胞在抵抗应激过程中的重要机制之一,一定程