caspase3基因的3’端非翻译区microrna结合位点rs1049216单核苷酸多态性与宫颈癌易感性的关系

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1、授予单位代码１００８９学号或申请号１３８９２巧作忘斜大ＳＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕壬学位论文■在职科学学位Ｃ＇ａｓｐａｓｅＳ基因的３端非翻译区ｍｉｃｒｏＲＮ乂结合位点ｒｓｌ０４９２１６单核昔酸多态性与宫颈癌易感性的关系学位申请人：李媛媛导师：董稚明教授专业；病理学与病理生理学二级学院：第四医院２０１５年１０月河北医科大学学位论文使用授巧及知识产巧归属巧诺本学位论文在导师（或指导小组）的指导下，由本人独立堯成。本学位论文研究所获得的研巧成果，其知识产较归河北医科大学所。河北医稱大

2、学有巧对本学位论文进行交流、公开和使用有。凡发表一与学位论文主要內容相关的论文，第署名力单位河北医科大学，试验材輯、原始数据、申报的专利等知识产权均归河北医科大学巧有。否则，承担相应法律责任。．ｖ＇，，研究生签名导师签章二级学院领导羞焉：ｆｊ年月日？／河北医科大学研究生学位论文独创巧寅明本论文是在导师指导下迸行的研究工作及取得的研究成果，除了文中持别加标注和致谢等內容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名导师签章：年曰月目录中文摘要·······

3、········································································1英文摘要···············································································3英文缩写···············································································6研究论文Caspase3基因的3'端非翻译区microRNA结合位点rs1049216单核苷酸多态性与宫颈

4、癌易感性的关系前言···············································································8材料与方法·····································································10结果··············································································17附图·············································

5、·································19附表··············································································22讨论··············································································26结论··············································································30参考文献·········

6、·······························································31综述microRNA单核苷酸结合位点多态性与恶性肿瘤发病风险的相关性··························································36致谢····················································································47个人简历···········································

7、···································58中文摘要Caspase3基因的3'端非翻译区microRNA结合位点rs1049216单核苷酸多态性与宫颈癌易感性的关系摘要目的：宫颈癌为女性生殖系统肿瘤中最为常见的恶性肿瘤之一，排在女性恶性肿瘤发病率的第三位。在我国宫颈癌发病率在女性生殖道恶性肿瘤中高居于榜首。近年来宫颈癌的发病年龄越来越趋于年轻化，严重威胁着广大女性的生命及健康。MicroRNA是广泛存在不同物种间的内源性非编码短序列RNA