ogd诱导dsrna活化nlrp3信号通路及其相关炎性因子在脑损伤中的作用机制

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1、分类号R651.1第四军医大学UDC616.8TheFourthMilitaryMedicalUniversity密级公开硕士学位论文OGD诱导dsRNA活化NLRP3信号通路及其相关炎性因子在脑损伤中的作用机制王利培养类别全日制学位类型学术学位一级学科(专业类)临床医学二级学科(专业)外科学（神外）研究方向缺血性脑损伤的诊治指导教师费舟教授（主任医师）培养单位西京医院神经外科二O一五年五月第四军医大学硕士学位论文目录缩略语表···········································

2、····················································1中文摘要·······························································································3英文摘要·······························································································6前言···

3、···························································································10文献回顾······························································································11正文·······························································

4、·······························18第一部分OGD诱导HT22细胞产生B1RNA形式的dsRNA·························181实验材料······················································································182方法········································································

5、····················223结果····························································································284讨论····························································································32第二部分B1RNA和NLRP3在小鼠MCAO模型以及原代神经元细胞中的表达··341

6、实验材料······················································································342实验方法······················································································363结果······································································

7、······················434讨论····························································································49第三部分B1RNA以及NLRP3通路相关因子在HT22细胞OGD模型上的表达及关系·················································································501实验材料········

8、··············································································502实验方法······················································································543结果··················