microrna-21在骨肉瘤细胞mg63中作用机制的研究

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1、分类号R738.1UDC616.7密级公开microRNA-21在骨肉瘤细胞MG63中作用机制的研究赵健培养类别全日制学位类型学术学位一级学科(专业类)临床医学二级学科(专业)外科学（骨外）研究方向miRNA在骨肉瘤细胞中的作用机制研究指导教师范清宇教授（主任医师）培养单位唐都医院骨科二O一五年五月第四军医大学博士学位论文目录缩略语表···························································································1中文摘要

2、···························································································3英文摘要···························································································6前言··········································································

3、···············10文献回顾·························································································12正文·························································································21实验一miR-21在骨肉瘤细胞MG63中的表达····································

4、··211材料·························································································212方法·························································································233结果·····································································

5、····················264讨论·························································································28实验二miR-21对骨肉瘤细胞MG63生物学特性的影响·························301材料·························································································30

6、2方法·························································································313结果·························································································344讨论·········································································

7、················38实验三miR-21对骨肉瘤细胞MG63顺铂耐药性的研究···························401材料·························································································402方法·························································································413结

8、果·························································································424讨论·························································