苹果多酚50%乙醇提取物对抗溃疡性结肠炎的作用及其机制研究

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1、HebeiMedicalUniversity硕士学位论文在职科学学位苹果多酚50%乙醇提取物对抗溃疡性结肠炎的作用及其机制研究学位申请人：刘国庆导师：蔡德海教授宋光明副教授专业：药理学二级学院：武警后勤学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下,由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法

2、律责任。研究生签名_师签章：^^二级学院领导盖章；A':�:�•:年nr日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：丄卜旬炎导师签章：斤年r月？。曰目录中文摘要·············································································1英文摘要······························

3、···············································4研究论文苹果多酚50%乙醇提取物对抗溃疡性结肠炎的作用及其机制研究前言·············································································7材料与方法····································································9结果···················································

4、··························16附图·············································································19附表·············································································27讨论·············································································29结论···············

5、······························································31参考文献·······································································33综述膳食剂在炎症性肠病中应用的研究进展·····························36致谢···················································································44个人简历······

6、·······································································45中文摘要苹果多酚50%乙醇提取物对抗溃疡性结肠炎的作用及其机制研究摘要目的：炎症性肠病（inflammatoryboweldiseases,IBD），临床表现以血性腹泻，腹部绞痛，疼痛，是一种免疫介导的影响肠粘膜的易复发的慢性疾病。IBD患者，相比与普通人群，也更高易患结直肠癌。克罗恩病（Crohn'sdisease,CD）和溃疡性结肠炎（ulcerativecolitis,UC）是炎症性肠病最常见的两种形式。溃疡性结肠炎的病

7、变范围广，病情易反复，并且其确切发病机制目前尚不清楚，因此目前对溃疡性结肠炎的治疗难度较大。现代医学主要以5-氨基水杨酸、类固醇激素、免疫抑制剂三大类药物进行治疗。但是，5-氨基水杨酸类是非特异性抗炎药物，对于溃疡性结肠炎只能起到暂时控制及缓解症状的效果，无法从根本上治疗疾病且服用该药物后会出现头痛、肾毒性等毒副作用，停药后病情易反复。苹果能降低某些癌症、心血管疾病、哮喘、糖尿病发病的风险。苹果的提取物苹果多酚中含有好几种黄酮类化合物和某些植物化学物质，包括槲皮素苷，儿茶素，表儿茶素，原花青素，矢车菊素半乳糖苷，香豆酸，绿原酸，没食子酸和