生长分化因子-15血清水平及基因多态位点+2438cgrs1058587与急性心肌梗死的相关性

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1、授予单位代码10089学号或申请号13486H妗(E科大空HebeiMedicalUniversity硕士学位论文在职科学学位生长分化因子-15血清水平及基因多态位点+2438C/G:rsl058587与急性心肌梗死的相关性学位申请人：罗东雷导师：李拥军教授专业：内科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与

2、学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。，、一研究生签名导师..级学院领导盖章：

3、年月y河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名导师签年ir月目录中文摘要······································

4、·······································1英文摘要·············································································3英文缩写·············································································6研究论文生长分化因子-15血清水平及基因多态位点+2438C/G:rs1058587与急性心肌梗死的相关性前言···

5、··········································································7材料与方法····································································7结果·············································································15附图······························

6、···············································16附表·············································································19讨论·············································································21结论·················································

7、····························25参考文献·······································································26综述生长分化因子-15及其基因多态性研究·······························30致谢···················································································39个人简历···········

8、··································································40中 文 摘 要生长分化因子-15血清水平及基因多态位点+2438C/G:rs1058587与急性心肌梗死的相关性摘要目的：通过测定急性心肌梗死（AMI）与非冠心病（NCHD）患者的GDF-15血清水平及基因多态位点+2438C/G:rs1058587基因多态性，探讨GDF-15血清水平是否与急性心肌梗死有关，并探讨GDF-15基因多态位点rs1058587与急性心肌梗死的相关性，为急性

9、心肌梗死的预防和预后评价提供研究依据。方法：选取急性心肌梗死组和非冠心病组作为研究对象，收集临床资料，测定血糖、尿酸、肌酐、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、高敏C反应蛋白、GDF-15血清水平，并对GDF-15基因多态位点+2438C/G:rs1058587做基因多态性分析。数据采用SPSS22.0统计