血清生长分化因子-15与急性心肌梗死后左室重构程度的相关性研究

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1、ᄺ᷵ҷⷕ˖ߚ㉏ো˖⸩຿ᄺԡ䆎᭛㸔⏙⫳䭓ߚ࣪಴ᄤ-15Ϣᗹᗻᖗ㙠ṫ⅏ৢᎺᅸ䞡ᵘ⿟ᑺⱘⳌ݇ᗻⷨおⷨお⫳˖䛁╂ᣛᇐᬭᏜ˖⠯޵ϧϮৡ⿄˖ݙ⾥ᄺⷨおᮍ৥˖ᖗᕟ༅ᐌϢᖗ⮙ⱘ䆞ᮁϢ⊏⭫ᄺԡ㉏ൟ˖ϧϮᄺԡ᠔೼ᄺ䰶˖㄀ϔЈᑞएᄺ䰶Ё೑ቅ㽓Ѡ0ϔϝᑈಯ᳜Ѡकϝ᮹ቅ㽓ए⾥໻ᄺ⸩຿ᄺԡ䆎᭛ߚ㉏ো˖ऩԡҷⷕ˖10114ᆚ㑻˖ᄺো˖201020649㸔⏙⫳䭓ߚ࣪಴ᄤ-15Ϣᗹᗻᖗ㙠ṫ⅏ৢᎺᅸ䞡ᵘ⿟ᑺⱘⳌ݇ᗻⷨおⷨお⫳˖䛁╂ᣛᇐᬭᏜ˖⠯޵⬇䇋ᄺԡ䮼㉏㑻߿˖एᄺ⸩຿˄ϧϮᄺԡ˅ϧϮৡ⿄˖ݙ⾥ᄺⷨおᮍ৥˖ᖗᕟ༅ᐌϢᖗ⮙ⱘ䆞ᮁϢ⊏⭫᠔೼ᄺ䰶˖ቅ㽓ए⾥໻ᄺ㄀ϔЈᑞएᄺ䰶2013ᑈ4᳜23᮹ቅ㽓ए⾥໻ᄺ⸩຿ᄺԡ䆎᭛ቅ㽓ए⾥໻ᄺ⸩຿

2、ᄺԡ䆎᭛ⳂᔩЁ᭛ᨬ㽕…………………………………………………1㣅᭛ᨬ㽕…………………………………………………2㓽⬹䆡㸼…………………………………………………4ℷ᭛……………………………………………………………5ࠡ㿔……………………………………………………………5ᇍ䈵੠ᮍ⊩……………………………………………………6㒧ᵰ……………………………………………………………9䅼䆎……………………………………………………………12㒧䆎……………………………………………………………15খ㗗᭛⤂………………………………………………………16㓐䗄……………………………………………………………18ℷ᭛…………………

3、………………………………………18খ㗗᭛⤂……………………………………………………24㟈䇶……………………………………………………………27ϾҎㅔҟ…………………………………………………28ቅ㽓ए⾥໻ᄺ⸩຿ᄺԡ䆎᭛㸔⏙⫳䭓ߚ࣪಴ᄤ-15Ϣᗹᗻᖗ㙠ṫ⅏ৢᎺᅸ䞡ᵘ⿟ᑺⱘⳌ݇ᗻⷨおЁ᭛ᨬ㽕Ⳃⱘ㾖ᆳᗹᗻᖗ㙠ṫ⅏ᙷ㗙ঞℷᐌҎ㸔⏙⫳䭓ߚ࣪಴ᄤ-15˄GDF-15˅∈ᑇⱘব࣪ঞ݊Ϣᖗ㙠ṫ⅏ৢᎺ᠓ࠡৢᕘǃᎺᅸ㟦ᓴ᳿ᕘǃᎺᅸ䋼䞣ᣛ᭄ǃᎺᅸⳌᇍᅸຕ८ᑺǃᇘ㸔ߚ᭄ⱘⳌ݇ᗻˈ᥶䅼GDF-15Ϣᗹᗻᖗ㙠ṫ⅏ৢᎺᅸ䞡ᵘ⿟ᑺⱘⳌ݇ᗻDŽᮍ⊩䗝পᗹᗻᖗ㙠ṫ⅏ᙷ㗙50՟ߚЎϸ㒘ˈᎺᖗᅸ䞡ᵘ㒘30՟ˈ᮴Ꮊᖗᅸ䞡ᵘ㒘20՟DŽℷᐌᇍ

4、✻㒘30՟DŽ䞛䲚໪਼䴭㛝㸔ˈ䞛⫼䝊㘨ܡ⭿਌䰘⊩Ẕ⌟㸔⏙ЁGDF-15∈ᑇDŽ䍙ໄᖗࡼ೒⌟ᅮᎺ᠓ࠡৢᕘǃᎺᅸ㟦ᓴ᳿ᕘǃ㟦ᓴ᳿Ꮊᅸৢຕ८ᑺǃ㟦ᓴ᳿ᅸ䯈䱨८ᑺˈᇘ㸔ߚ᭄ㄝᎺᅸ䞡ᵘᣛᷛDŽ㒧ᵰ1.Ꮊᖗᅸ䞡ᵘ㒘GDF-15ⱘ㸼䖒∈ᑇ੠᮴Ꮊᖗᅸ䞡ᵘ㒘ⱘGDF-15⌧ᑺഛ催Ѣℷᐌᇍ✻㒘˄P<0.01˅DŽᎺᖗᅸ䞡ᵘ㒘ⱘGDF-15⌧ᑺ催Ѣ᮴Ꮊᖗᅸ䞡ᵘ㒘˄P<0.01˅DŽ2.GDF-15⌧ᑺϢᑈ啘ǃᗻ߿ǃԧ䞡ǃ催㸔य़⮙ǃ催㸔㛖ǃ㊪ሓ⮙ǃ਌⚳ǃ佂䜦ǃ催ᆚᑺ㛖㲟ⱑǃԢᆚᑺ㛖㲟ⱑǃ⫬⊍ϝ䝃ǃ催ᬣCডᑨ㲟ⱑഛϡⳌ݇ˈϢᘏ㚚೎䝛ਜ䋳Ⳍ݇˄P=0.04˅ˈϢ㛥䩴㚑ਜℷⳌ݇˄P<0.01˅DŽ3.GDF-15ϢᎺ᠓ࠡৢᕘ˄r=0

5、.745,P<0.01˅ǃᎺᅸ㟦ᓴ᳿ᕘ˄r=0.84,P<0.01˅ǃᎺᅸ䋼䞣ᣛ᭄˄r=0.993,P<0.01˅ਜℷⳌ݇˗Ϣᇘ㸔ߚ᭄˄r=-0.65,P<0.01˅ǃⳌᇍᅸຕ८ᑺ˄r=-0.96,P<0.01˅ਜ䋳Ⳍ݇DŽ4.䞛প໮ܗ㒓ᗻಲᔦߚᵤˈ᥻ࠊњᑈ啘ǃᗻ߿੠ᖗ㸔ㅵॅ䰽಴㋴ৢˈGDF-15∈ᑇϢᎺᅸ䋼䞣ᣛ᭄ਜℷⳌ݇˄B=0.91ˈP<0.01˅DŽ㒧䆎GDF-15೼ᗹᗻᖗ㙠ṫ⅏ⱘᖗ㙠㒚㚲Ё催ᑺ㸼䖒ˈখϢᗹᗻᖗ㙠ṫ⅏ৢᎺᅸ䞡ᵘⱘ䖛⿟ˈ݊∈ᑇϢᎺᅸ䞡ᵘ⿟ᑺਜᰒ㨫ⱘǃ⣀ゟⱘⳌ݇ᗻDŽ݇䬂䆡㸔⏙⫳䭓ߚ࣪಴ᄤ-15ˈᗹᗻᖗ㙠ṫ⅏ˈᎺᅸ䞡ᵘˈᖗ࡯㹄チ1ቅ㽓ए⾥໻ᄺ⸩຿ᄺԡ䆎᭛Associationbe

6、tweenSerumGrowthDifferentiationFactor15levelandLeftVentricleRemodelingaftertheAcuteMyocardialInfarctionAbstractObjectiveToobservechangesintheleveloftheGrowthdifferentiationfactor15(GDF-15)inpatientswithacutemyocardialinfarctionandnormal;andanalysistheexpressionwithleftatriumdimension,leftventricula

7、rend-diastolicclassics,leftventricularmassindex,relativewallthickness,leftventricular,ejectionfractionandleftventricularremodelingindex,wehypothesizedthatGDF-15wereassociatedtotheextentofleftventricularremo