原发性高血压患者血清ghrelin和hcy水平的变化及其临床意义

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1、授予单位代码10089学号或申请号13227HebeiMedicalUniversity硕士学位论文在职科学学位原发性高血压患者血清Ghrelin和Hey水平的变化及其临床意义学位申请人：刘丽丽导师：高磊教授专业：内科学二级学院：第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获的研宄成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，

2、承担相应的法律责任。导师签章:河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导老师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要··············································································1英文摘要··············································································3

3、英文缩写··············································································5研究论文原发性高血压患者血清Ghrelin和Hcy水平的变化及其临床意义前言··············································································6材料与方法·····································································7结果·················

4、····························································10附表·············································································12讨论·············································································14结论····································································

5、·········19参考文献·······································································19综述血清Ghrelin和Hcy水平与原发性高血压关系研究进展.··········22致谢···················································································32个人简历········································································

6、·····33中文摘要原发性高血压患者血清Ghrelin和Hcy水平的变化及其临床意义摘要目的:通过检测定州市体检人群中原发性高血压（primaryhypertension）患者血清中生长激素促分泌素受体（growthhormonesecretagoguereceptorGHSR）的内源性配体Ghrelin水平的及同型半胱氨酸（HomocysteineHcy）的水平,观察与正常对照组是否存在差异，进而探讨Ghrelin水平及Hcy水平的变化与原发性高血压之间的相关性,为进一步研究高血压的发病因素及治疗提供一个新的切入点。方法：选择自2013年9月至2014年12月在定州市人民医院健

7、康体检中心体检发现的原发性高血压患者，共90例，年龄40岁以上至59岁之间，参照《2010中国高血压防治指南》的诊断标准进行诊断，按高血压分级又分为三个亚组，其中一级高血压组30人、二级高血压组30人、三级高血压组30人；选择同年龄段健康志愿者50例作对照组，所有入选者均检查身高、体重、体重指数、血常规、血糖、血脂、肝肾功能、同型半胱氨酸、Ghrelin、心电图、心脏彩超、胸片；经病史、查体、化验结果和心电图诊断排除继发性高血压，糖尿病、高脂血症、高尿酸血症、肝肾功能