阿托伐他汀雌激素疗法对大鼠卵巢去势骨质疏松模型治疗作用的研究

《阿托伐他汀雌激素疗法对大鼠卵巢去势骨质疏松模型治疗作用的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码１００８９１学号或申请号１３９５７Ｗ＾（￡钟夫２ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕±学位论文在职科学学位阿托伐他汀／雌激素疗法对大鼠卵巢去势曾质疏松模型治疗作用的研究学位申请人：田利军Ｉ导师：孟創教授专业；外科学二级学院：河北省儿童医院２０１５年１０月河北医科大学学位论义使用授权及知巧产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表

2、与学位论文主要内容相关的论文一，第署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。—研究生签名Ｘ咬今化导师签章二级学院领导盖＾＾１＾ｆ年月河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果。本论文由本人，指导教师对此迸行了审定独立撰写。，文责自负研究生签名：：导师签韋梦＾年月曰＜ｆ目录中文摘要····································

3、··········································1英文摘要··············································································4英文缩写··············································································7研究论文阿托伐他汀/雌激素疗法对大鼠卵巢去势骨质疏松模型治疗作用的研究前言···················································

4、···························8材料与方法·····································································9结果··············································································12附图··············································································17附表····························

5、··················································24讨论··············································································31结论··············································································32参考文献········································································32综述骨

6、质疏松治疗方案研究进展··············································35致谢····················································································45个人简历··············································································49中文摘要阿托伐他汀/雌激素疗法对大鼠卵巢去势骨质疏松模型治疗作用的研究摘要目的:骨质疏松，又成为骨质疏松症（osteoporosis

7、，OP），是由多种因素导致的以单位体积内骨组织量减少、骨微细结构发生改变、骨的硬度降低及脆性增加，从而导致骨折的危险性大大增加为特征的一种慢性代谢性骨病变。骨质疏松的发生是由于骨的形成和吸收之间的动态过程失衡所导致的，多发于绝经后妇女。目前，对骨质疏松的治疗所采取有效的药物治疗包括：雌激素、二磷酸盐类、选择性雌激素受体调节剂（selectiveestrogenreceptormodulators,SERMs）等均属于抗骨吸收的药物。