滤泡性辅助t细胞及滤泡性调节t细胞在结直肠癌患者外周血中的表达及其临床意义

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1、授予单位代码10089学号或申请号20123188HebeiMedicalUniversity硕士学位论文专业学位滤泡性辅助T细胞及滤泡性调节T细胞在结直肠癌患者外周血中的表达及其临床意义研究生：赵召龙导师：李中信教授专业：外科学2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学

2、，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名左导师签章:t二级学院领导盖章：>/淨)•驗台,河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研宄生签名:导师签章月7SX0日lo)S目录中文摘要··················································

3、·······························1英文摘要·················································································4英文缩写·················································································8研究论文滤泡性辅助T细胞及滤泡性调节T细胞在结直肠癌患者外周血中的表达及其临床意义前言·············

4、····································································9材料与方法······································································10结果···············································································13附图·····························

5、··················································15附表···············································································20讨论···············································································21结论········································

6、·······································24参考文献·········································································25综述滤泡性辅助T细胞（Tfh）与人相关疾病的研究·················30致谢·····················································································53个人简历····

7、···········································································54中文摘要滤泡性辅助T细胞及滤泡性调节T细胞在结直肠癌患者外周血中的表达及其临床意义摘要背景：结直肠癌是全世界发病率排名第三的恶性肿瘤，每年有超过100万患者确诊为结直肠癌。传统治疗手段（手术，化疗，放疗，靶向治疗）疗效不理想。除了肿瘤本身的机制外，肿瘤微环境特别是炎症反应、免疫反应与肿瘤的进展甚至放化疗、靶向药物抵抗有关。可以说,肿瘤免疫治疗的时代已经到来。事实上

8、越来越多的证据表明,在预防肿瘤的发生、生长和转移扩散中免疫系统扮演重要的角色。+对于CD4T淋巴细胞亚群的研究是近年来免疫学研究的一个热点。+Tfh作为CD4T淋巴细胞亚群的一种，是近年来研究发现的一种特殊的辅助性T细胞，表达CXCR5的Tfh细胞在CXCL13的趋化下，被募集到淋巴滤泡，参与诱导B细胞的分化及生发中心的形成，通过产生IL-21等细胞因子以及