滑膜肉瘤组织中foxp3及ki-67的表达情况及临床意义

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1、授予单位代码10089学号或申请号20122326蚵於(E搿走迳HebeiMedicalUniversity硕士学位论文科学学位滑膜肉瘤组织中Foxp3及Ki-67的表达情况及临床意义研究生：赵亚恒导师：冯建刚教授专业：外科学二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署例单位为

2、河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责任。.研究生签名签章：二级学院领导盖章：年j月>日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包含其他人己发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名^导师签章：丨)月>日1目录中文摘要·························································

3、····················1英文摘要·············································································3英文缩写·············································································6研究论文滑膜肉瘤组织中Foxp3及Ki-67的表达情况及临床意义前言··········································

4、···································7材料与方法····································································9结果·············································································12附图····································································

5、·········14附表·············································································16讨论·············································································21结论·············································································25参考文献···

6、····································································25综述Foxp3及滑膜肉瘤的研究进展.……………………………………..27致谢···················································································47个人简历································································

7、·············48中文摘要滑膜肉瘤组织中Foxp3及Ki-67的表达情况及临床意义摘要目的：通过免疫组织化学方法研究Foxp3及Ki-67在滑膜肉瘤组织中表达情况，分析二者表达的相关性，探讨其与滑膜肉瘤的复发、转移、肿瘤大小以及临床分期的关系。以了解Foxp3及Ki-67的表达是否与临床预后有相关性。方法：选择2007年1月至2013年3月在河北医科大学第四医院骨科手术切除的98例滑膜肉瘤石蜡组织标本，另取15例脂肪瘤石蜡组织标本作为对照组。应用兔抗人Foxp3多克隆抗体及兔抗人Ki-67多克隆抗体，采用

8、免疫组织化学SP法检测肿瘤组织中Foxp3、Ki-67的表达状况。统计分析Foxp3及Ki-67的表达与滑膜肉瘤肿瘤大小、临床分期、复发、转移的相关性，并对98例滑膜肉瘤病例进行整理，确立影响滑膜肉瘤预后的因素。结果：1试验对象113例，其中脂肪瘤15例，初发型滑膜肉瘤29例，复发型滑膜肉瘤55例，转移型滑膜肉瘤14例。四组患者年龄均数在44-