不同剂量阿托伐他汀对老年不稳定型心绞痛血清五聚素3影响的研究

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1、授予单位代码10089学号或申请号13123HebeiMedicalUniversity硕士学位论文在职科学学位不同剂量阿托伐他汀对老年不稳定型心绞痛血清五聚素3影响的研究学位申请人：马晓英导师：姜志安教授专业：内科学二级学院：第三医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承

2、担相应法律责任。研究生签名：力导师签章：二级学院领导盖章：河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名导师签章:IC年目录中文摘要·············································································1英文摘要·························································

3、····················3研究论文不同剂量阿托伐他汀对老年不稳定型心绞痛血清五聚素3影响的研究前言·············································································5资料与方法····································································6结果·············································································9附表········

4、·····································································11讨论·············································································13结论·············································································16参考文献······························································

5、·········16综述不稳定型心绞痛发病机制及PTX-3与急性冠脉综合征的发生、发展和预后的关系························································20致谢···················································································32个人简历·············································································33中文摘要不同剂量阿托伐他汀对老年不稳定型心

6、绞痛血清五聚素3影响的研究摘要目的：研究不同剂量的阿托伐他汀对老年不稳定型心绞痛血清五聚素3的影响。方法：选取2013-12～2014-2在承德市中心医院老年病科和心内科住院不稳定型心绞痛患者60例，阿托伐他汀20mg/d（A组）；阿托伐他汀80mg/d（B组），同时选择同期来我院健康体检中心体检的健康者20人作为正常对照组（C组）。给药前、给药一个月后、给药三个月后分别检测患者PTX-3、尿常规、血常规、肾功、肝功、心肌酶谱、TG、TC、HDL-C、LDL-C、血糖等指标，并统计患者心脏事件的发生情况。结果:用药前A、B两组受试者的一般情况（年龄、性别、吸烟、血压、血糖、心功能、血脂、PT

7、X-3、既往冠脉造影及支架植入）等方面无统计学意义(P>0.05)。A、B组的血脂、PTX-3水平高于正常对照组（C组）水平，差异有统计学意义(P<0.05)。PTX-3水平：用药一个月及三个月后A、B两组血清PTX-3水平较用药前显著下降，且B组血清PTX-3水平较A组下降更显著，差异具有统计学意义(P<0.05)，但A、B两组仍高于正常对照组（C组）PTX-3的水平。TC水平：用药三个月后B组患者血TC水