tlr4调控的神经炎症在术后认知功能障碍发病机制中的作用

《tlr4调控的神经炎症在术后认知功能障碍发病机制中的作用》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、分类号：R614单位代码：10312密级：学号：20122118博士学位论文题目：TLR4调控的神经炎症在术后认知功能障碍发病机制中的作用研究生：陆顺梅指导教师：钱燕宁学科专业：麻醉学学院名称：南京医科大学第一临床医学院完成时间：二○一五年四月南京医科大学学位论文原创性声明本人郑重声明：所呈交的论文是本人在导师的指导下，独立进行研究工作。所取得的成果陈了文中特别加Ｗ标注引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写的成果作品。对本义的研究做出重要贡献的个人和集体，均已在文中Ｗ明确方式标明。本人完全意识到本声明的法律后

2、果由本人承担。作者签名：文日期年６月８日导师签名日期：叫巧日（月》学位论文版权使用授权书本学位论文作者完全了解学校有关保留，、使用学位论文的规定同意学校保留并向国家有关部口或机构送交论文的复印件和电子版，允许论文彼查阅和借阅。本人授权南京医科大学可Ｗ将本学位论文的全部或部分内容编入有关数据库进行检索，可采用影印、缩印或扫描等复制手段保存和汇编本学位论文。＂＂本学位论文属于（请在Ｗ下相应方框内打Ｖ）；１、保密，在年解密后适用本授权书。＿２、不保密口。作者签名：日期：：＾畔６月ｇ日导师签名日期：八（

3、Ｉ年《月ｄ日＾目录中英文缩略词对照表··································································································1摘要······························································································································4Abstract·····················

4、····································································································9正文第一部分氯化锂预处理可能通过抑制小胶质细胞表面TLR4的活化改善老年大鼠脾脏切除手术后认知功能的下降前言··························································································································

5、··13参考文献····················································································································15材料与方法················································································································19结果······························

6、······························································································32讨论····························································································································42参考文献·················································

7、···································································47结论····························································································································54第二部分S100A8调控小鼠胫骨骨折手术后的认知功能障碍依赖于TLR4/MyD88信号通路的活化前言······························

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