nf-κb（p65）在小儿局灶性皮质发育不良（fcd）ⅲ a中的表达分析

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1、授予单位代码10089学号或申请号13198HebeiMedicalUniversity硕士学位论文在职科学学位NF-KB(P65)在小儿局灶性皮质发育不良�FCD)111a中的表达分析学位申请人：郝改领导师：娄燕教授李文玲教授专业：儿科学二级学院：河北省人民医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有•河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文

2、，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名导师签章絲二_鴨績粉_日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。导师签章:目录中文摘要··································································

3、···········1英文摘要·············································································4英文缩写·············································································7研究论文NF-κB(P65)在小儿局灶性皮质发育不良（FCD）IIIa中的表达分析前言············································

4、·································8材料与方法····································································9结果·············································································15附图········································································

5、·····16附表·············································································19讨论·············································································22结论·············································································25参考文献·········

6、······························································26综述NF-κB在癫痫中的研究进展············································30致谢···················································································41个人简历··············································

7、·······························42中文摘要NF-κB(P65)在小儿局灶性皮质发育不良IIIa中的表达分析摘要研究背景：小儿癫痫是一种神经系统综合征，它的病因及发作形式复杂，临床上以反复发作、刻板发作为特点，居儿童期脑部慢性疾病的第一位，是一种致残性的疾病。它主要因为大脑神经元被多种原因诱导致异常同步放电，进一步导致了中枢神经系统功能障碍。小儿癫痫严重影响患儿的身心健康，亦给家庭和社会带来了沉重的负担。癫痫中约30％为药物难治性癫痫(refractoryepilepsy,RE)，现有药物难

8、以控制癫痫发作，需要手术治疗切除致痫灶。在手术治疗的难治性癫痫患儿中，约有75%为局灶性皮质发育不良(focalcorticaldysplasia，FCD)。FCD是大脑皮质发育不良的亚型之一，其被认为是在胚胎发育早期神经元的正常程序（如增殖迁移分化等）受到干扰所致，其典型的病理改变是皮质分层异常和/或出现异形、异位